Genome architecture. (A) Heatmap indicating the switching of core (grey) and noncore (dark grey) transcriptional macro-regions during fermentation as follows: black histogram (left panel) shows % of GC with low GC demarcating region border; gene expression (left/middle panel (red and Blue); centred to mean) and transposon expression (red right panel). Together gene expression and transposons show a structured genomic organisation relative to macro-region architecture. (B) Two alternative genetic programs are demarcated at the switch by a bottleneck event that is readily apparent in transcriptomic data. Significant enrichment for functional gene categories at different stages of the growth cycle is indicated.