Determination of dosage compensation of the mammalian X chromosome by RNA-seq is dependent on analytical approach

BMC Genomics

Table 2 RXE across paralogs

	Human brain	Human liver	Human lymphoblast 45, X^m	Human lymphoblast 45, X^p	Human lymphoblast
cis-paralogs	2.57 (41, 30) ^†	0.18 (31, 28)	0.51 (13, 18)	0.79 (14, 17)	0.24 (38, 31)
trans-paralogs	−0.64 (76, 43) ^*	0 (69, 40)	0.20 (56, 31)	−0.55 (61, 63)	−0.06 (77, 44)
all paralogs	0.49 (106, 65) ^†	0.03 (93, 60)	0.14 (66, 43)	−0.15 (68, 46)	0.19 (104, 70)
non-paralogs	−0.18 (415, 546) ^*	−0.5 (378, 520) ^*	−0.32 (269, 393) ^*	−0.38 (272, 412) ^*	−0.73 (400, 559) ^*

Relative X-chromosome expression values across both cis and trans-paralogs for five human libraries. Cis-paralogs show an increased RXE compared to trans-paralogs and non-paralogous elements. Bolded value identifies case where X chromosome and autosome expression are significantly different from each other (p < 0.05, Kolmogorov-Smirnov test, with bootstrapping −1000 replicates). Cross indicates X chromosome expression greater than autosomes, while asterisk indicates X chromosome expression less than autosomes.

ISSN: 1471-2164