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Table 3 QTL, sex and direction-of-cross effects ( p < 0.001) in the G 3 population at age of 10 weeks

From: Effect of the myostatin locus on muscle mass and intramuscular fat content in a cross between mouse lines selected for hypermuscularity

Trait

QTL/Effect1

Chr

Mb2

CI3

Marker4

LOD5

a (s.e.)6

d (s.e.)6

% G3 var7

Body weight (g)

sex

    

83.01

8.43 (0.31)

 

68.35

 

pgm

    

6.44

1.67 (0.3)

 

2.81

 

1@27.0

1

54

47-59

rs31991963

8.93

−1.25 (0.21)

−1.03 (0.31)

3.97

Lean mass (g)

sex

    

62.43

5.74 (0.27)

 

55.22

 

pgm

    

7.78

1.59 (0.26)

 

4.42

 

1@27.0

1

54

47-55

rs31991963

13.91

−1.35 (0.18)

−1.2 (0.26)

8.27

ML-Mass (g)

sex

    

14.30

0.1 (0.01)

 

15.31

 

pgm

    

3.43

0.04 (0.01)

 

3.38

 

1@27.0

1

54

47-59

rs31991963

17.26

−0.07 (0.01)

−0.07 (0.01)

18.90

MQ-Mass (g)

sex

    

8.68

0.07 (0.01)

 

10.86

 

pgm

    

2.50

0.03 (0.01)

 

2.98

 

1@27.0

1

54

47-55

rs31991963

7.17

−0.04 (0.01)

−0.04 (0.01)

8.88

Fat mass (g)

sex

    

35.31

1.98 (0.15)

 

40.23

 

16@55.0

16

94

86-94

rs3143713

3.57

−0.07 (0.12)

−0.55 (0.15)

3.16

Fat mass (%)

sex

    

15.49

2.97 (0.36)

 

18.85

 

1@27.0

 

54

47-59

rs31991963

6.32

1.03 (0.24)

1.15 (0.35)

7.17

IMF-ML (%)

sex

    

20.04

0.28 (0.03)

 

22.55

 

1@27.0

1

54

47-55

rs31991963

10.15

0.13 (0.02)

0.06 (0.03)

10.56

IMF-MQ (%)

sex

    

50.46

0.41 (0.02)

 

37.56

 

pgm

    

39.19

−0.01 (0.03)

 

26.50

 

1@26.0

1

51

47-59

rs31991963

10.05

0.07 (0.01)

0.00 (0.02)

5.36

 

sex:pgm

    

16.08

−0.29 (0.03)

 

9.00

  1. 1 QTL positions are given as chromosome number, @, and the genetic distance from the centromer in cM.
  2. 2 Most likely chromosomal location given as Mb-position.
  3. 3 1-LOD support interval in Mb.
  4. 4 Marker closest to the chromosomal position with the highest LOD score.
  5. 5 LOD scores from the full model estimations.
  6. 6 additive (a) and dominance (d) effect and their standard errors (s.e.) determined with the non-transformed raw trait values, therefore given in the respective unit; the direction of a and d, respectively given as the effect of the BMMI866-allele.
  7. 7 G3 phenotypic variance (%) explained by the QTL; QTL effect given as the reduction of the residual sum of squares fitting 1 vs. 0 QTL.