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Table 3 Phenotypes of lipid metabolic genes inactivated by RNAi

From: Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans

Sequence name Gene name LDs LD size Other phenotypes Pathway Key references
C49F5.1 sams-1 increased Growth rate variant, lean, sterile Glycerophospholipid metabolism [20, 21]
C05D11.7 atgl increased   Glycerolipid metabolism [51, 52]
F14F3.3 mboa-7 increased   Glycerophospholipid metabolism [17, 18]
C10F3.2 dhs-16 increased Egg laying defect, growth rate variant, lethal, slim Primary bile acid biosynthesis [50]
C56G2.6 let-767 increased Growth rate variant, slim, lethal, egg laying defect Steroid hormone biosynthesis,Linoleic acid metabolism,Biosynthesis of unsaturated fatty acids [49, 53]
H37A05.1 lpin-1 decreased Growth rate variant, slim, egg laying defect Glycerophospholipid metabolism [54, 55]
C23H3.4 sptl-1 decreased Egg laying defect, lethal,pale Sphingolipid metabolism [16]
F46E10.1 acs-1 decreased Growth rate variant, slim, larvae arrest, lethal Fatty acid metabolism, Glycerophospholipid metabolism [56, 57]
T19B10.1 cyp-29A2 decreased Egg laying defect, lethal Arachidonic acid metabolism  
VZK822L.1 fat-6 decreased Growth rate variant, sterile, pale, slim Biosynthesis of unsaturated fatty acids [14, 5860]
T27F6.6    Egg laying defect Sphingolipid metabolism  
ZC416.8 cha-1   Egg laying defect Glycerophospholipid metabolism [6164]
K12H4.5    Reduced brood size, growth rate variant (l3-l4,72 h normal) Glycerophospholipid metabolism  
F25B4.6 hmgs-1   Growth rate variant, larval arrest, larval lethal,sterile Synthesis and degradation of ketone bodies  
F56D1.5 dhs-5   Egg laying defect Steroid hormone biosynthesis  
T02G5.8 kat-1   Growth rate variant (L3,72 h normal) Synthesis and degradation of ketone bodies [65, 66]
F32H2.5 fasn-1   Larval arrest, lethal Fatty acid synthesis [8, 22, 67]
W09B6.1 pod-2   Larval arrest, lethal Fatty acid synthesis [22, 68, 69]
F11E6.5 elo-2   Pale, slim Fatty acid synthesis [14, 70]
D2024.3 elo-3   Pale, slim, egg laying defect unclear  
T01E8.3 plc-3   Sterile Glycerophospholipid metabolism [7173]