Table 3 Phenotypes of lipid metabolic genes inactivated by RNAi

C49F5.1

sams-1

increased

Growth rate variant, lean, sterile

Glycerophospholipid metabolism

[20, 21]

C05D11.7

atgl

increased

Glycerolipid metabolism

[51, 52]

F14F3.3

mboa-7

increased

Glycerophospholipid metabolism

[17, 18]

C10F3.2

dhs-16

increased

Egg laying defect, growth rate variant, lethal, slim

Primary bile acid biosynthesis

[50]

C56G2.6

let-767

increased

Growth rate variant, slim, lethal, egg laying defect

Steroid hormone biosynthesis,Linoleic acid metabolism,Biosynthesis of unsaturated fatty acids

[49, 53]

(4)

H37A05.1

lpin-1

decreased

Growth rate variant, slim, egg laying defect

Glycerophospholipid metabolism

[54, 55]

C23H3.4

sptl-1

decreased

Egg laying defect, lethal,pale

Sphingolipid metabolism

[16]

F46E10.1

acs-1

decreased

Growth rate variant, slim, larvae arrest, lethal

Fatty acid metabolism, Glycerophospholipid metabolism

[56, 57]

T19B10.1

cyp-29A2

decreased

Egg laying defect, lethal

Arachidonic acid metabolism

VZK822L.1

fat-6

decreased

Growth rate variant, sterile, pale, slim

Biosynthesis of unsaturated fatty acids

[14, 58–60]

T27F6.6

Egg laying defect

Sphingolipid metabolism

ZC416.8

cha-1

Egg laying defect

Glycerophospholipid metabolism

[61–64]

K12H4.5

Reduced brood size, growth rate variant (l3-l4,72 h normal)

Glycerophospholipid metabolism

F25B4.6

hmgs-1

Growth rate variant, larval arrest, larval lethal,sterile

Synthesis and degradation of ketone bodies

F56D1.5

dhs-5

Egg laying defect

Steroid hormone biosynthesis

T02G5.8

kat-1

Growth rate variant (L3,72 h normal)

Synthesis and degradation of ketone bodies

[65, 66]

F32H2.5

fasn-1

Larval arrest, lethal

Fatty acid synthesis

[8, 22, 67]

W09B6.1

pod-2

Larval arrest, lethal

Fatty acid synthesis

[22, 68, 69]

F11E6.5

elo-2

Pale, slim

Fatty acid synthesis

[14, 70]

D2024.3

elo-3

Pale, slim, egg laying defect

unclear

T01E8.3

plc-3

Sterile

Glycerophospholipid metabolism

[71–73]