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Table 4 Differential expression of mammalian milk triglyceride synthesis genes in the ‘lactating’ crop

From: Transcriptome analysis of pigeon milk production – role of cornification and triglyceride synthesis genes

Gene symbol

Gene name

0/ctrl

+2/ctrl

Mice L2/P7

Triglyceride synthesis

 

Gyk

Glycerol kinase

1.49

1.92

1.26

Gpd1

Glycerol 3-PO4 dehydrogenase (cytosolic)

−1.50

−2.08

2.25

Acsl1

Long-chain Acyl-CoA synthetase 1

1.80

2.94

1.51

Acsl4

Long-chain-fatty-acid-CoA ligase 4

ns

−2.42

−1.35

Gpam; GPAT

Glycerol-3-phosphate acyltransferase

ns

2.03

−1.22

Agpat3

1-acylglycerol-3-phosphate O-acyltransferase 3*

ns

1.52

Na

Agpat9

1-acylglycerol-3-phosphate O-acyltransferase 9*

ns

2.38

Na

Dgat2

Diacylglycerol O-acyltransferase 2*

1.61

3.66

Na

Fatty acid plasma membrane transporters

 

Slc27a1

Fatty acid transporter, member 1

−2.21

−2.21

−1.01

Slc27a4

Fatty acid transporter, member 4

ns

2.01

1.99

Cd36

Fatty acid translocase

2.69

5.57

1.08

Fatty acid binding proteins

 

Fabp3

Fatty acid binding protein 3, muscle and heart

−3.17

−4.88

−1.02

Fabp5

Fatty acid binding protein 5

ns

2.92

1.31

Fatty acid degradation

 

Lpl

Lipoprotein lipase

1.66

2.08

1.24

Cte1

Cytosolic acyl coenzyme A thioester hydrolase

ns

1.59

−16.66

Crat

Carnitine acetyltransferase IA

ns

1.35

Na

Crat

Carnitine acetyltransferase IB

ns

−2.02

na

Cpt2; CPTII

Carnitine acetyltransferase II

ns

1.43

−2.56

Ech1

Enoyl coenzyme A hydratase 1, peroxisomal

ns

1.69

−2.08

Hadhsc

L-3-hydroxyacyl-Coenzyme A dehydrogenase

ns

1.49

−1.20

LOC231086

Betaketothiolase

ns

1.23

−1.56

Fatty acid synthesis

 

Acly

ATP citrate lyase

1.46

1.88

2.66

Mdh1

Malate dehydrogenase, cytosolic

1.19

1.23

1.07

Mod1

Malic enzyme, cytosolic

1.41

2.17

1.54

ACC

Acetyl CoA carboxylase

1.68

2.26

Na

Fasn

Fatty acid synthase

1.60

2.46

1.65

Scd1

Stearoyl-Coenzyme A desaturase 1

ns

2.00

1.55^

Scd5

Stearoyl-Coenzyme A desaturase 5*

−1.45

−1.48

Na

Fads1

Fatty acid desaturase 1

ns

−2.22

2.40

Elovl4

Elongation of very long chain fatty acids 4*

ns

−7.28

Na

Elovl5

Elongation of very long chain fatty acids 5*

ns

−2.05

Na

Elovl6

Elongation of very long chain fatty acids 6*

1.32

1.63

Na

Thrsp; Lpgp

Spot 14, thyroid hormone-inducible hepatic protein

ns

−4.90

1.89

  1. Average fold-change of significantly (p < 0.05) differentially expressed triglyceride synthesis genes in the ‘lactating’ pigeon crop at timepoint 0 and +2 as compared to the non-‘lactating’ crop. ns = not significant. Values for lactating mouse mammary gland versus pregnant [19] are given for comparison.
  2. * = pigeon differentially expressed variant, not examined in mouse.
  3. ^ = average of 2 values.