Table 3 Most significant canonical pathways determined by Ingenuity Pathway Analysis and represented in the assembled gilthead sea bream transcriptome
Canonical pathway | E-value | Molecules | Canonical pathway | E-value | Molecules |
|---|---|---|---|---|---|
Regulation of eIF4 and p70S6K Signaling | 1.58E-23 | 130 | Erythropoietin Signaling | 8.32E-08 | 56 |
Purine Metabolism | 7.94E-23 | 219 | Ubiquinone Biosynthesis | 9.12E-08 | 58 |
EIF2 Signaling | 3.98E-21 | 156 | AMPK Signaling | 9.33E-08 | 100 |
Protein Ubiquitination Pathway | 7.94E-20 | 207 | Induction of Apoptosis by HIV1 | 1.05E-07 | 51 |
Glucocorticoid Receptor Signaling | 2.51E-17 | 203 | IL-2 Signaling | 1,17E-07 | 46 |
mTOR Signaling | 2.51E-16 | 148 | CD40 Signaling | 1,20E-07 | 53 |
Molecular Mechanisms of Cancer | 6.31E-16 | 250 | Role of NFAT in Cardiac Hypertrophy | 1,29E-07 | 131 |
Mitochondrial Dysfunction | 1.00E-15 | 114 | HGF Signaling | 1,48E-07 | 77 |
Integrin Signaling | 6.31E-14 | 155 | FLT3 Signaling in Hematopoietics | 1,55E-07 | 59 |
Inositol Phosphate Metabolism | 2.51E-13 | 122 | Progenitor Cells | ||
Thrombin Signaling | 1.58E-12 | 147 | Fcγ Receptor-mediated Phagocytosis in | 1,58E-07 | 73 |
Signaling by Rho Family GTPases | 1.58E-12 | 174 | Macrophages and Monocytes | ||
Estrogen Receptor Signaling | 3.16E-12 | 104 | Sphingosine-1-phosphate Signaling | 1,66E-07 | 86 |
CXCR4 Signaling | 5.01E-12 | 121 | FAK Signaling | 1,66E-07 | 69 |
Oxidative Phosphorylation | 6.31E-12 | 115 | Paxillin Signaling | 2,09E-07 | 78 |
Acute Phase Response Signaling | 7.94E-12 | 130 | Small Cell Lung Cancer Signaling | 2,40E-07 | 58 |
Breast Cancer Regulation by Stathmin1 | 1.26E-11 | 147 | T Cell Receptor Signaling | 3,31E-07 | 75 |
Type II Diabetes Mellitus Signaling | 3.98E-11 | 94 | B Cell Receptor Signaling | 3,31E-07 | 105 |
Huntington’s Disease Signaling | 5.01E-11 | 161 | Production of Nitric Oxide and Reactive | 3,72E-07 | 126 |
Pyrimidine Metabolism | 7.94E-11 | 111 | Oxygen Species in Macrophages | ||
NGF Signaling | 7.94E-11 | 86 | LPS-stimulated MAPK Signaling | 3,89E-07 | 59 |
PI3K/AKT Signaling | 1.10E-10 | 96 | Insulin Receptor Signaling | 3,98E-07 | 96 |
RAR Activation | 1.38E-10 | 130 | Cyclins and Cell Cycle Regulation | 3,98E-07 | 63 |
Androgen Signaling | 1.62E-10 | 91 | PI3K Signaling in B Lymphocytes | 4,57E-07 | 99 |
Tight Junction Signaling | 1.86E-10 | 120 | IGF-1 Signaling | 4,68E-07 | 76 |
Chronic Myeloid Leukemia Signaling | 4.68E-10 | 78 | p53 Signaling | 5,25E-07 | 72 |
NRF2-mediated Oxidative Stress Response | 8.51E-10 | 134 | VEGF Signaling | 5,62E-07 | 68 |
PPARα/RXRα Activation | 1.12E-09 | 128 | Prostate Cancer Signaling | 6,03E-07 | 64 |
Actin Cytoskeleton Signaling | 1.78E-09 | 154 | Nicotinate and Nicotinamide Metabolism | 6,46E-07 | 77 |
Ceramide Signaling | 2.00E-09 | 66 | Relaxin Signaling | 6,46E-07 | 98 |
Role of Tissue Factor in Cancer | 2.29E-09 | 87 | Glioma Signaling | 7,24E-07 | 73 |
Hereditary Breast Cancer Signaling | 3.31E-09 | 92 | Pentose Phosphate Pathway | 7,94E-07 | 29 |
ERK/MAPK Signaling | 3.72E-09 | 135 | Pancreatic Adenocarcinoma Signaling | 8,13E-07 | 80 |
NF-κB Activation by Viruses | 4.57E-09 | 62 | Mitotic Roles of Polo-Like Kinase | 8,51E-07 | 51 |
Apoptosis Signaling | 4.68E-09 | 73 | Acute Myeloid Leukemia Signaling | 9,33E-07 | 61 |
Gα12/13 Signaling | 4.90E-09 | 93 | PDGF Signaling | 9,33E-07 | 57 |
Cardiac Hypertrophy Signaling | 5.13E-09 | 159 | CNTF Signaling | 1,05E-06 | 44 |
Rac Signaling | 5.37E-09 | 83 | Endometrial Cancer Signaling | 1,05E-06 | 44 |
Germ Cell-Sertoli Cell Junction Signaling | 6.17E-09 | 118 | Thrombopoietin Signaling | 1,17E-06 | 46 |
ILK Signaling | 6.76E-09 | 135 | Melanocyte Development and Pigmentation | 1,29E-06 | 66 |
Renin-Angiotensin Signaling | 7.94E-09 | 86 | Signaling | ||
Protein Kinase A Signaling | 8.51E-09 | 212 | Prolactin Signaling | 1,45E-06 | 58 |
Aldosterone Signaling in Epithelial Cells | 8.91E-09 | 117 | Colorectal Cancer Metastasis Signaling | 1,58E-06 | 161 |
RhoGDI Signaling | 9.12E-09 | 129 | RANK Signaling in Osteoclasts | 1,82E-06 | 67 |
p70S6K Signaling | 1.00E-08 | 95 | IL-17A Signaling in Airway Cells | 2,19E-06 | 51 |
IL-8 Signaling | 1.02E-08 | 127 | Aminoacyl-tRNA Biosynthesis | 2,40E-06 | 30 |
IL-15 Signaling | 1.15E-08 | 53 | G Beta Gamma Signaling | 2,51E-06 | 68 |
fMLP Signaling in Neutrophils | 1.23E-08 | 85 | Telomerase Signaling | 2,69E-06 | 75 |
Phospholipase C Signaling | 1.78E-08 | 163 | IL-6 Signaling | 3,16E-06 | 71 |
PAK Signaling | 1.91E-08 | 72 | Role of BRCA1 in DNA Damage Response | 3,24E-06 | 46 |
P2Y Purigenic Receptor Signaling Pathway | 2.24E-08 | 93 | Death Receptor Signaling | 3,39E-06 | 48 |
HMGB1 Signaling | 3.02E-08 | 75 | IL-3 Signaling | 3,39E-06 | 56 |
Leukocyte Extravasation Signaling | 3.16E-08 | 137 | Starch and Sucrose Metabolism | 3,47E-06 | 54 |
RhoA Signaling | 3.89E-08 | 86 | GM-CSF Signaling | 3,47E-06 | 50 |
PTEN Signaling | 4.07E-08 | 84 | Angiopoietin Signaling | 3,47E-06 | 52 |
Virus Entry via Endocytic Pathways | 4.57E-08 | 72 | Non-Small Cell Lung Cancer Signaling | 3,47E-06 | 52 |
Growth Hormone Signaling | 5.13E-08 | 57 | Role of NFAT in Regulation of the Immune | 3,72E-06 | 120 |
JAK/Stat Signaling | 6.31E-08 | 52 | Response | ||
Lymphotoxin β Receptor Signaling | 7.08E-08 | 47 | Neuregulin Signaling | 3,72E-06 | 67 |