Figure 5

Amino acid sequence variability in the AMA1-binding site of RON2 paralogs. The amino acid sequence of the AMA1-binding site of TgRON2 (red bar) was aligned with the corresponding regions of TgRON2 iso1 (TGME49_094400) and TgRON2 iso2 (TGME49_065120). The C-terminal transmembrane domains (TMD2 and TMD3) of the three paralogs are highlighted in grey. Conserved amino acids within the AMA1-binding sequence are framed in black, those lying in the flanking regions are bolded. Asterisks indicate RON2 amino acid residues playing a crucial role in AMA1 binding [46].