Temporal global host cell expression changes during RSV-infection. (A) The genes showing up-regulated and down-regulated gene expression that are unique to either 4 or 24 hrs post-infection (hpi) or common to both 4 and 24 hpi are indicated in the venn diagram. T is the total number of genes at each time using the fold change cut-off. (B) The numbers of genes based on gene ontology showing up-regulated or down-regulated expression in the microarray analysis of RSV-infected MΦ cells are summarized. The genes showing changes in expression levels were filtered based on ≥2-fold, ≥5-fold and ≥10-fold changes (P ≤ 0.05). Genes showing ≥10 fold down-regulated expression following virus infection were not detected.