Different canonical pathways in RSV-infected PMФ cells based on macrophage host genes showing differential gene expression (A) 4 and (B) 24 hours post-infection (hpi). The microarray data sets for each time of infection was processed using GeneSpring GX 11.0 and uploaded into Ingenuity Pathways Analysis version 2012 (IPA). The data was filtered based on the significance cutoff ≤0.05 and fold change cutoff ≥2. Genes were categorized using IPA, and p-values were calculated by Fisher’s exact test for each canonical pathway at 4 and 24 hpi, and the top 10 statistically significant canonical pathways were identified at each time of infection and listed. The number of genes listed for each pathway is indicated in the parentheses. The orange boxes indicate the ratio (Ratio) of the numbers of genes that show changes in gene expression data and the total number of genes in the respective canonical pathway. Threshold was set at p-value = 0.05 and indicated as –log (p-value) on the Y-axis and the X-axis shows the terms of each canonical pathway.