Table 5 Candidate regulators in the telomere group of eQTL hotspots
eQTL Hotspot | Candidate | Differentially Expressed? | Mutations | Function |
|---|---|---|---|---|
IV:1500Â kb | YRF1-1 | 6.4e-6 | 5 base insertion 186 nt upstream | YRF1 gene |
X:20Â kb | YJL225C | 1.1e-4 | 10 base insertion 237nt upstream | YRF1-like gene |
XII:780Â kb | EST2 | No | 5 missense | Telomerase component, reverse transcriptase |
NUP2 | No | 7 missense | Nuclear pore protein involved in telomere silencing | |
XII:1070Â kb | SIR3 | 5.3e-3 | 12 missense | Involved in telomere silencing |
| Â | RIF2 | No | 6 missense | Involved in telomere silencing |