Characterization of RNA editing sites in editing boxes. (A) The genomic distribution of constitutive A-to-I editing box sites. (B) Comparison of predicted constitutive editing box sites with other studies [8–10, 27] and DARNED database. 695 (about 31%) constitutive editing sites in clusters were previously unreported, compared with 1550 (69%) sites were overlapped with at least one dataset (left panel). Only a few sites were reported from multiple datasets (right panel). (C) The genomic distribution of newly identified editing box sites. (E) The distribution of newly identified editing box sites in IRAlus, within or over 1 kb to IRAlus regions. (D) The distribution of newly identified editing box sites in Alu, non-Alu repetitive or non-repetitive regions.