Table 3 Comparison of predicted clustered and non-clustered constitutive A-to-I sites
A | ||||||
|---|---|---|---|---|---|---|
A-to-I conversions | A-to-Is in H9 and HeLa | Numbers of validated sites | ||||
Clustered sites | 2,245 | 296 | 22 of 22 | |||
Non-clustered sites | 10,220 | 1,542 | 7 of 15 | |||
B | ||||||
Predicted A-to-I sites | Predicted A-to-I ratios | Validation | ||||
Chr. location | Altered base | Gene location | H9 | HeLa | H9 | HeLa |
chr1:40041484 | A- > G (+) | Coding | 28.1% | 29.5% | − | − |
chr4:184186228 | A- > G (+) | Coding | 30.8% | 28.1% | − | − |
chr6:159187882 | A- > G (+) | 3′UTR | 46.2% | 50% | − | − |
chr7:44841489 | A- > G (+) | 3′UTR | 78.4% | 69.2% | + | + |
chr8:48890109 | A- > G (+) | 3′UTR | 29.6% | 32.5% | + | + |
chr10:75008955 | A- > G (−) | 3′UTR | 59.5% | 65.8% | + | + |
chr17:4068050 | A- > G (+) | 3′UTR | 31.8% | 31.7% | − | − |
chr17:61898921 | A- > G (−) | Coding | 27.5% | 16.9% | + | + |
chr17:80445942 | A- > G (+) | Coding | 34.4% | 32.1% | − | − |
chr19:10755103 | A- > G (−) | 3′UTR | 95.3% | 96.7% | − | − |
chr19:34718735 | A- > G (+) | 3′UTR | 46.5% | 27.9% | + | + |
chr19:39874895 | A- > G (+) | 3′UTR | 36.1% | 38.9% | − | − |
chr20:30253695 | A- > G (+) | 3′UTR | 20.0% | 29.9% | − | − |
chrX:54589730 | A- > G (+) | 3′UTR | 30.0% | 46.3% | + | + |
chrX:54589774 | A- > G (+) | 3′UTR | 6.9% | 8.8% | + | + |