Integrative model for ZGA combining transcription and epigenetic factors. (A) Chromatin state and factor organisation before ZGA. (B) Chromatin opening and transcriptional activation. Supporting evidences: letters (from a to j) indicate the clues brought by literature (blue), by our bioinformatics treatments (red), or both (purple). (a) See Figure 4, Additional file 15: Figure S11B and ; (b) See ; (c) See Additional file 15: Figure S11B; (d,e) See [16, 17]; (f) See Figure 4, Additional file 10: Figure S7 and ; (g) See Figure 4, Additional file 15: Figure S11B; (h) See Additional file 10: Figure S7, Figure 7 and .