Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

Table 2 Number of SNVs identified through exome sequencing of 11 mouse strains

Strains	SAMP1/ TaSlc	SAMP3/ SlcIdr	SAMP6/ TaSlc	SAMP8/ TaSlc	SAMP10/ TaSlc	SAMP11/ SlcIdr	SAMR1/ SlcIdr	SAMR1/ TaSlc	SAMR3B/ SlcIdr	AKR/J	C57BL/6J
Total SNVs	112245	85198	90734	97039	106341	104290	108059	108880	121527	100463	3484
Exonic SNVs	35791	32019	32659	34048	35752	35817	36174	38432	38925	32816	1407
Homozygous	28916	26142	27914	26142	29282	29310	30253	25891	31338	26880	158
Non-synonymous	7364	6811	7106	7435	7429	7413	7588	6507	7843	6903	63
Novel	310	260	316	273	317	286	317	230	491	245	39
Total MNVs	2251	1610	1757	1870	2093	2007	2207	2210	2245	1834	67
Exonic MNVs	529	433	478	473	528	511	535	571	539	407	22
Homozygous	404	346	375	393	428	412	406	420	417	349	14
Non-synonymous	258	228	243	260	279	273	262	274	294	215	12
Novel	49	33	48	43	50	48	51	63	32	32	8
Total Indels	4439	3189	3653	3932	4446	4286	4749	4287	4943	3988	111
Exonic Indels	470	371	406	413	478	494	505	498	554	411	33
Homozygous	83	64	65	62	69	68	81	77	94	76	3
Frameshift	11	8	8	9	7	8	10	10	14	8	0
Novel	3	2	4	6	2	3	4	3	7	2	0
Total Gain of Stops	242	125	149	155	158	153	177	246	253	132	30
Homozygous	72	56	68	76	61	67	73	57	68	60	1
Novel	10	2	4	6	8	5	10	8	5	1	1

ISSN: 1471-2164