Table 4 Top 5 overrepresented GO terms within the 6 genes including missense SNVs detected among all of the SAMP strains, but absent in the SAMR and AKR/J strains
GO ID | GO category | Number of reference genes in the category | Number of genes in the gene set and also in the category | Expected number in genes in the gene set | Raw p-value | Adjusted p-value | Gene symbol |
|---|---|---|---|---|---|---|---|
GO:0006284 | base-excision repair | 17 | 2 | 0.01 | 1.35×10-5 | 0.0003 | Mbd4, Ogg1 |
GO:0006281 | DNA repair | 213 | 2 | 0.08 | 0.0022 | 0.0202 | Mbd4, Ogg1 |
GO:0006950 | response to stress | 1107 | 3 | 0.39 | 0.0042 | 0.0202 | Alox5, Mbd4, Ogg1 |
GO:0034984 | cellular response to DNA damage stimulus | 243 | 2 | 0.09 | 0.0028 | 0.0202 | Mbd4, Ogg1 |
GO:0006974 | response to DNA damage stimulus | 274 | 2 | 0.1 | 0.0036 | 0.0202 | Mbd4, Ogg1 |