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Table 5 Novel deleterious mutations detected among multiple SAMP strains, but absent in the SAMR and AKR/J strains

From: Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

Location Gene symbol Gene name Nucleotide change (cDNA) Amino acid change Strains SIFT score Polyphen-2 score
Chr14:35357289 Ldb3 LIM domain binding 3 c.1555G>A p.R473W SAMP1/SkuSlc,SAMP3/SlcIdr,SAMP6/TaSlc, SAMP10/TaSlc, SAMP11/SlcIdr 0.02 0.968
Chr14:57654538 Gja3 gap junction protein, alpha 3 c.1427A>G p.S405P SAMP3/SlcIdr,SAMP6/TaSlc, SAMP10/TaSlc, SAMP11/SlcIdr 0.09 0.917
Chr7:28301176 Prx periaxin c.784C>T p.R167C SAMP3/SlcIdr, SAMP10/TaSlc, SAMP11/SlcIdr 0.01 0.998
Chr11:49958661 Tbc1d9b TBC1 domain family, member 9B c.560T>C p.S161P SAMP3/SlcIdr, SAMP10/TaSlc 0 0.867
Chr11:70277672 Zmynd15 zinc finger, MYND-type containing 15 c.1859C>T p.T461M SAMP3/SlcIdr, SAMP10/TaSlc 0.05 N.A.
Chr18:37455608 Pcdhb2 protocadherin beta 2 c.1115G>A p.G327R SAMP10/TaSlc, SAMP11/SlcIdr 0 N.A.
Chr18:37495244 Pcdhb6 protocadherin beta 6 c.1563G>T p.E521D SAMP10/TaSlc, SAMP11/SlcIdr 0 N.A.
  1. Human protein sequence is in conflict with the mouse sequence at the position indicated.