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Table 5 Novel deleterious mutations detected among multiple SAMP strains, but absent in the SAMR and AKR/J strains

From: Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

Location

Gene symbol

Gene name

Nucleotide change (cDNA)

Amino acid change

Strains

SIFT score

Polyphen-2 score

Chr14:35357289

Ldb3

LIM domain binding 3

c.1555G>A

p.R473W

SAMP1/SkuSlc,SAMP3/SlcIdr,SAMP6/TaSlc, SAMP10/TaSlc, SAMP11/SlcIdr

0.02

0.968

Chr14:57654538

Gja3

gap junction protein, alpha 3

c.1427A>G

p.S405P

SAMP3/SlcIdr,SAMP6/TaSlc, SAMP10/TaSlc, SAMP11/SlcIdr

0.09

0.917†

Chr7:28301176

Prx

periaxin

c.784C>T

p.R167C

SAMP3/SlcIdr, SAMP10/TaSlc, SAMP11/SlcIdr

0.01

0.998

Chr11:49958661

Tbc1d9b

TBC1 domain family, member 9B

c.560T>C

p.S161P

SAMP3/SlcIdr, SAMP10/TaSlc

0

0.867

Chr11:70277672

Zmynd15

zinc finger, MYND-type containing 15

c.1859C>T

p.T461M

SAMP3/SlcIdr, SAMP10/TaSlc

0.05

N.A.

Chr18:37455608

Pcdhb2

protocadherin beta 2

c.1115G>A

p.G327R

SAMP10/TaSlc, SAMP11/SlcIdr

0

N.A.

Chr18:37495244

Pcdhb6

protocadherin beta 6

c.1563G>T

p.E521D

SAMP10/TaSlc, SAMP11/SlcIdr

0

N.A.

  1. †Human protein sequence is in conflict with the mouse sequence at the position indicated.