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Table 6 Novel deleterious mutations specific to SAMP6/TaSlc

From: Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

Location Gene symbol Gene name Nucleotide change (cDNA) Amino acid change SIFT score Polyphen-2 score
Chr2:29947531 Zdhhc12 zinc finger, DHHC domain containing 12 c.381G>A p.R112C 0 0.999
Chr2:31793494 Lamc3 laminin gamma 3 c.4202A>G p.D1380G 0.05 0.399
Chr7:132719753 Il4ra interleukin 4 receptor, alpha c.1860delC p.S540fs N.A. N.A.
Chr10:79474903 Abca7 ATP-binding cassette, sub-family A (ABC1), member 7 c.5477G>A p.R1826H 0.01 0.108
Chr15:99998371 Dip2b DIP2 disco-interacting protein 2 homolog B c.1708G>A p.A544T 0.05 0.17
Chr17:25257897 Ptx4 pentraxin 4 c.176A>T p.R34S 0* 0.999
Chr19:4153338 Coro1b coronin, actin-binding protein 1B c.1253C>T p.R393W 0 0.998
  1. *The score is low confidence because the prediction was based on sequences too closely related.