Changes in the transcriptome of the malaria parasite Plasmodium falciparumduring the initial phase of transmission from the human to the mosquito

Ngwa, Che Julius; Scheuermayer, Matthias; Mair, Gunnar Rudolf; Kern, Selina; Brügl, Thomas; Wirth, Christine Clara; Aminake, Makoah Nigel; Wiesner, Jochen; Fischer, Rainer; Vilcinskas, Andreas; Pradel, Gabriele

doi:10.1186/1471-2164-14-256

Table 2 Comparison of genes identified by SSH with P. falciparum and P. berghei gametocyte proteome data

From: Changes in the transcriptome of the malaria parasite Plasmodium falciparumduring the initial phase of transmission from the human to the mosquito

			Pf	P. falciparumGC				P. bergheimale/female GC							Total
PF_ID	Gene Ontology	MW	Troph	I & II	IV & V	V	I.II.IV.V	FG1	FG 3	FG (1+3)	MG1	MG3	MG (1+3)	FG +MG	FG.MG.PF	PB_ID
PF3D7_0210600	signaling	53.7	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_030750
PF3D7_0214600	signaling	204.3	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_031140
PF3D7_0302100	signaling	157.4	2	3	1	7	11	0	0	0	0	0	0	0	11	PBANKA_040110
PF3D7_0303900	signaling	23.2	0	4	4	11	19	0	0	0	0	0	0	0	19	PBANKA_040250
PF3D7_0515300	signaling	255.9	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_111490
PF3D7_0530200	signaling	59.8	0	0	0	3	3	0	0	0	0	0	0	0	3	PBANKA_124460
PF3D7_0624000	signaling	55.3	17	20	2	24	46	6	13	19	11	10	21	40	86	PBANKA_112290
PF3D7_0818200	signaling	30.2	18	21	14	25	60	11	20	31	9	11	20	51	111	PBANKA_071260
PF3D7_0927200	signaling	189.7	0	13	2	5	20	0	0	0	0	0	0	0	20	PBANKA_082800
PF3D7_1004300	signaling	131.7	3	5	1	0	6	0	0	0	0	0	0	0	6	PBANKA_120260
PF3D7_1113100	signaling	25.1	1	2	1	3	6	0	0	0	0	0	0	0	6	PBANKA_093450
PF3D7_1230900	signaling	111.5	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_144560
PF3D7_1233600	signaling	146.3	0	4	0	8	12	0	0	0	0	0	0	0	12	PBANKA_144820
PF3D7_1238100	signaling	266.4	7	9	3	9	21	2	6	8	8	7	15	23	44	PBANKA_145260
PF3D7_1238900	signaling	58.9	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_145340
PF3D7_1356800	signaling	475.7	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_113310
PF3D7_1358600	signaling	118.3	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_113490
PF3D7_1403900	signaling	35.2	6	9	5	12	26	×	×	×	×	×	×	×	26	×
PF3D7_1433400	signaling	682.5	0	0	2	0	2	0	0	0	0	0	0	0	2	PBANKA_101150
PF3D7_1442200	signaling	118.7	0	0	1	0	1	0	0	0	0	0	0	0	1	PBANKA_130610
PF3D7_1463900	signaling	127.1	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_132710
PF3D7_1464600	signaling	170.5	23	31	0	3	34	0	0	0	0	0	0	0	34	PBANKA_132800
PF3D7_0420300	cell cycle & gene expr.	400.2	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_052170
PF3D7_0513600	cell cycle & gene expr.	129.2	10	29	0	10	39	0	0	0	0	0	0	0	39	PBANKA_111330
PF3D7_0615400	cell cycle & gene expr.	323.2	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_123010
PF3D7_0622900	cell cycle & gene expr.	237.4	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_112180
PF3D7_0811300	cell cycle & gene expr.	200.2	0	2	1	2	5	0	0	0	0	0	0	0	5	PBANKA_142620
PF3D7_0827800	cell cycle & gene expr.	283.6	0	0	1	0	1	0	0	0	0	0	0	0	1	PBANKA_070290
PF3D7_1011800	cell cycle & gene expr.	131.6	41	22	6	17	45	4	11	15	14	0	14	29	74	PBANKA_121020
PF3D7_1018500	cell cycle & gene expr.	12.5	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_050270
PF3D7_1019000	cell cycle & gene expr.	280.8	7	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_050320
PF3D7_1034900	cell cycle & gene expr.	101.2	21	31	0	49	80	6	0	6	3	0	3	9	89	PBANKA_051870
PF3D7_1103800	cell cycle & gene expr.	392.0	7	12	0	23	35	0	0	0	0	0	0	0	35	PBANKA_094310
PF3D7_1105500	cell cycle & gene expr.	20.1	1	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_094140
PF3D7_1115200	cell cycle & gene expr.	94.3	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_093250
PF3D7_1347500	cell cycle & gene expr.	42.2	18	15	30	22	67	11	0	11	7	10	17	28	95	PBANKA_136030
PF3D7_1360900	cell cycle & gene expr.	44.8	8	11	11	12	34	×	×	×	×	×	×	×	34	×
PF3D7_1417200	cell cycle & gene expr.	519.8	5	6	0	6	12	0	0	0	0	0	0	0	12	PBANKA_102550
PF3D7_1445900	cell cycle & gene expr.	60.0	16	25	3	21	49	0	0	0	1	0	1	1	50	PBANKA_130970
PF3D7_1469700	cell cycle & gene expr.	24.6	0	2	0	3	5	0	0	0	0	0	0	0	5	PBANKA_133290
PF3D7_0422300	IMC, cytoskeleton	49.7	11	25	13	30	68	0	0	0	0	0	0	0	68	PBANKA_052270
PF3D7_0503400	IMC, cytoskeleton	13.7	6	5	1	8	14	0	0	0	0	1	1	1	15	PBANKA_110310
PF3D7_0515700	IMC, cytoskeleton	51.8	3	0	0	7	7	1	0	1	0	0	0	1	8	PBANKA_111530
PF3D7_0708000	IMC, cytoskeleton	103.6	0	0	2	12	14	0	0	0	1	0	1	1	15	PBANKA_080520
PF3D7_0724900	IMC, cytoskeleton	222.6	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_062240
PF3D7_0918000	IMC, cytoskeleton	44.6	14	12	1	23	36	0	0	0	0	0	0	0	36	PBANKA_081900
PF3D7_1020200	IMC, cytoskeleton	99.1	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_050430
PF3D7_1246200	IMC, cytoskeleton	41.2	23	28	13	29	70	12	19	31	6	6	12	43	113	PBANKA_145930
PF3D7_1246400	IMC, cytoskeleton	23.5	1	0	0	3	3	0	0	0	0	0	0	0	3	PBANKA_145950
PF3D7_1251200	IMC, cytoskeleton	69.0	1	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_146410
PF3D7_1351700	IMC, cytoskeleton	151.2	0	0	1	0	1	0	0	0	0	0	0	0	1	PBANKA_136440
PF3D7_0102200	proteostasis	126.5	33	3	1	0	4	×	×	×	×	×	×	×	4	×
PF3D7_0215400	proteostasis	110.8	0	0	1	0	1	0	0	0	0	0	0	0	1	PBANKA_031210
PF3D7_0306200	proteostasis	41.6	4	7	0	8	15	0	0	0	0	0	0	0	15	PBANKA_040460
PF3D7_0708400	proteostasis	86.2	54	60	17	82	159	7	0	7	8	10	18	25	184	PBANKA_080570
PF3D7_0807500	proteostasis	29.5	11	11	2	20	33	3	8	11	4	2	6	17	50	PBANKA_122310
PF3D7_0815800	proteostasis	214.7	0	3	0	0	3	0	0	0	0	0	0	0	3	PBANKA_071500
PF3D7_0818900	proteostasis	73.9	45	46	33	57	136	34	40	74	31	28	59	133	269	PBANKA_071190
PF3D7_0917900	proteostasis	72.4	45	40	42	51	133	24	46	70	16	16	32	102	235	PBANKA_081890
PF3D7_1136400	proteostasis	107.1	0	3	0	11	14	1	0	1	0	0	0	1	15	PBANKA_091220
PF3D7_1466300	proteostasis	132.8	23	26	3	34	63	4	9	13	4	0	4	17	80	PBANKA_132970
mal_mito_2	metabolism general	53.0	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_MIT0002
PF3D7_0104400	metabolism general	62.5	0	1	1	3	5	0	0	0	0	0	0	0	5	PBANKA_020870
PF3D7_0403200	metabolism general	69.4	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_100080
PF3D7_0511800	metabolism general	69.1	36	29	2	40	71	2	0	2	0	0	0	2	73	PBANKA_111140
PF3D7_0801900	metabolism general	552.0	0	0	1	0	1	0	0	0	0	0	0	0	1	PBANKA_122830
PF3D7_0806800	metabolism general	123.0	11	9	4	29	42	0	0	0	0	3	3	3	45	PBANKA_122380
PF3D7_0922200	metabolism general	44.8	25	16	0	4	20	1	2	3	0	0	0	3	23	PBANKA_082310
PF3D7_1444800	metabolism general	40.1	21	23	11	35	69	17	23	40	22	22	44	84	153	PBANKA_130860
PF3D7_0102500	cell surface & PVM	181.2	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_133270
PF3D7_0202500	cell surface & PVM	11.5	1	0	0	0	0	×	×	×	×	×	×	×	0	×
PF3D7_0406200	cell surface & PVM	16.7	3	9	34	17	60	×	×	×	×	×	×	×	60	×
PF3D7_0423700	cell surface & PVM	10.2	0	5	0	2	7	×	×	×	×	×	×	×	7	×
PF3D7_0707300	cell surface & PVM	103.6	3	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_080450
PF3D7_0731500	cell surface & PVM	174.6	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_133270
PF3D7_0930300	cell surface & PVM	195.7	77	0	3	0	3	0	0	0	0	0	0	0	3	PBANKA_083100
PF3D7_1021900	cell surface & PVM	267.4	11	26	4	31	61	0	0	0	0	0	0	0	61	PBANKA_112590/ PBANKA_141230
PF3D7_1028700	cell surface & PVM	58.1	0	0	1	11	12	0	0	0	0	0	0	0	12	PBANKA_051280
PF3D7_1033200	cell surface & PVM	38.9	11	16	0	4	20	×	×	×	×	×	×	×	20	×
PF3D7_1035300	cell surface & PVM	141.1	0	0	1	0	1	×	×	×	×	×	×	×	1	×
PF3D7_1035700	cell surface & PVM	80.3	10	0	0	0	0	×	×	×	×	×	×	×	0	×
PF3D7_1103500	cell surface & PVM	67.3	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_094340
PF3D7_1218800	cell surface & PVM	39.6	0	0	2	5	7	0	0	0	0	0	0	0	7	PBANKA_143440
PF3D7_1228600	cell surface & PVM	86.6	23	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_144330
PF3D7_1335300	cell surface & PVM	382.9	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_000220 + 10 more
PF3D7_0206200	others	62.7	0	0	0	2	2	0	0	0	0	0	0	0	2	PBANKA_030390
PF3D7_0207700	others	108.7	11	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_030480
PF3D7_0311600	others	84.0	0	0	0	5	5	0	0	0	0	0	0	0	5	PBANKA_040960
PF3D7_0320700	others	21.0	0	0	0	8	8	0	0	0	0	0	0	0	8	PBANKA_121780
PF3D7_0403800	others	83.4	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_100150
PF3D7_0709900	others	274.0	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_122050
PF3D7_0817600	others	112.2	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_071320
PF3D7_0930000	others	66.8	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_083070
PF3D7_1027800	others	44.2	17	9	14	18	41	0	0	0	0	0	0	0	41	PBANKA_051190
PF3D7_1033800	others	52.3	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_051760
PF3D7_1103100	others	13.0	2	2	5	4	11	1	0	1	0	0	0	1	12	PBANKA_094360
PF3D7_1207700	others	43.4	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_060620
PF3D7_1358800	others	17.3	8	6	4	9	19	8	5	13	1	0	1	14	33	PBANKA_113510
PF3D7_1408600	others	25.1	8	8	7	12	27	2	5	7	2	0	2	9	36	PBANKA_103390
PF3D7_1457000	others	47.6	0	0	0	0	0	2	0	2	0	1	1	3	3	PBANKA_132070
PF3D7_0202400	unknown	141.9	27	0	0	0	0	×	×	×	×	×	×	×	0	×
PF3D7_0411000	unknown	179.7	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_061240
PF3D7_0417400	unknown	822.4	0	0	1	0	1	0	0	0	0	0	0	0	1	PBANKA_071950
PF3D7_0508900	unknown	370.2	0	2	0	0	2	0	0	0	0	0	0	0	2	PBANKA_110850
PF3D7_0601900	unknown	14.7	0	0	0	1	1	×	×	×	×	×	×	×	1	×
PF3D7_0704100	unknown	425.3	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_080180
PF3D7_0730800.1	unknown	32.1	5	0	0	0	0	×	×	×	×	×	×	×	0	×
PF3D7_0904200	unknown	34.0	0	1	0	0	1	0	0	0	0	0	0	0	1	PBANKA_041720
PF3D7_1021700	unknown	830.2	0	0	0	1	1	1	0	1	0	0	0	1	2	PBANKA_050590
PF3D7_1023000	unknown	48.9	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_050720
PF3D7_1024800	unknown	171.1	4	33	15	33	81	0	0	0	0	0	0	0	81	PBANKA_050900
PF3D7_1026100	unknown	23.9	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_051030
PF3D7_1026600	unknown	196.5	0	0	0	0	0	×	×	×	×	×	×	×	0	×
PF3D7_1114600	unknown	39.6	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_093310
PF3D7_1124200	unknown	49.3	0	0	0	7	7	0	0	0	1	0	1	1	8	PBANKA_092410
PF3D7_1126700	unknown	110.1	0	1	0	0	1	0	0	0	0	0	0	0	1	PBANKA_092170
PF3D7_1225600	unknown	93.1	0	1	0	0	1	0	0	0	0	0	0	0	1	PBANKA_144050
PF3D7_1230100	unknown	61.5	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_144480
PF3D7_1239400	unknown	22.0	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_145390
PF3D7_1316700	unknown	73.4	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_141520
PF3D7_1321000	unknown	80.6	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_141930
PF3D7_1362600	unknown	32.1	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_113860
PF3D7_1438800	unknown	84.0	0	0	0	2	2	0	0	0	0	0	0	0	2	PBANKA_130270
PF3D7_1439600	unknown	22.6	0	6	0	10	16	1	0	1	0	0	0	1	17	PBANKA_130350
PF3D7_1451200	unknown	176.2	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_131490
PF3D7_1452400	unknown	107.5	0	0	0	0	0	0	0	0	0	0	0	0	0	PBANKA_131610

PF troph, peptide hits for gametocyte-less P. falciparum trophozoites [12, 13]; I & II, stage I & II P. berghei gametocyte [12, 13]; V, stage V P. falciparum gametocytes [9]; I.II.IV.V, sum of all P. falciparum gametocyte data; FG1, peptide hits from highly purified female P. berghei gametocyte sample 1 [22]; FG3, peptide hits from highly purified female P. berghei gametocytes sample 3 [22]; FG(1+3), sum of both; MG1, peptide hits from highly purified male P. berghei gametocyte sample 1 [22]; MG3, peptide hits from highly purified male P. berghei gametocyte sample 3 [22]; MG(1+3), sum of both; FG+MG, total number peptide hits from all four P. berghei gametocyte samples; total FG.MG.PF, total number of P. falciparum & P. berghei gametocyte peptide hits.

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