Effect of Distance on Regulation by CUX1. (A) Genes fromthe ENCODE array have been organized according to the distance betweentheir transcription start site (TSS) and the closest CUX1 binding site.The "0" column indicates genes where the CUX1 binding site overlaps thestart site. The histogram shows, for each interval of distance, thepercentage of genes that exhibit a 1.5 fold change in expressionfollowing p110 CUX1 overexpression or CUX1 knockdown. The total numberof genes within each interval is indicated within each column.(B) As in A, except that the regulation by CUX1 isexpressed as either activation by CUX1 or repression by CUX1. (C)As in A, but with a threshold of 1.25 fold change in expression.(D) As in B, but with a threshold of 1.25 fold changein expression.