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Table 17 Number of genes on the promoter array that are regulated in responseto CUX1 overexpression or CUX1 knockdown

From: Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on theENCODE array

Number of sites/target Number of targets Targets with profiling data 1.5 fold change 1.25 fold change
Any # 4706 4140 347 8.4% 1437 34.7%
1 3942 3527 278 7.9% 1182 33.5%
2+ 643 613 **69 11.2% ***255 41.6%
  1. Effect of the number of CUX1 binding sites on the probability thattarget genes exhibit a change in expression following p110 CUX1overexpression or CUX1 knockdown, depending on the number of CUX1binding site present in their promoter region. **:P < 0.01, ***:P < 0.001 on a Fisher'sexact test vs. genes whose promoter have only 1 CUX1 bindingsite.