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Table 2 Specific functional classes of genes differentially expressed during myogenic differentiation

From: Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes

 

Specific functional classes

Unique genes/cluster

% targets

P-value

FDR

Cluster code

 

Upregulated

     

1

Myogenesis

     
 

- muscle contraction

81

8,64

3,881E-19

7,23E-16

1_up

 

- muscle development

145

13,79

6,37E-09

1,19E-05

2_up

 

- embryonic development

85

11,76

0,0001374

0,255618

3_up

2

Metabolism

     
 

- cellular respiration

179

12,85

2,21E-24

4,12E-21

4_up

 

- phosphate metabolism

217

13,82

2,459E-16

4,11E-13

5_up

 

- cofactor biosynthesis

57

12,28

5,177E-09

9,64E-06

6_up

 

- carbohydrate metabolism

50

18,00

1,556E-06

0,002898

7_up

3

Signaling

     
 

- insulin receptor signaling

132

19,70

2,61E-07

0,000486

8_up

4

Transcription

     
 

- transcription (+) reg

220

15,00

2,624E-07

0,000489

9_up

 

Downregulated

     

1

cell cycle

     
 

- cell cycle regulation

285

35,09

1,04E-51

1,95E-48

1_down

 

- chromosome segregation

42

26,19

2,51E-15

4,77E-12

2_down

 

- M-phase

31

32,26

3,75E-07

0,000702

3_down

 

- interphase

34

20,59

2,9E-08

5,43E-05

4_down

 

- DNA replication

38

34,21

8,04E-06

0,015052

5_down

 

- centrosome cycle

19

15,79

1,6E-06

0,002987

6_down

2

DNA damage response

     
 

- DNA damage response

253

39,53

2,8E-38

5,23E-35

7_down

 

- telomere maintenance

24

29,17

3,02E-05

0,056435

8_down

3

Wound healing/angiogensis

     
 

- wound healing

58

44,83

5,52E-08

0,000103

9_down

 

- angiogenesis

54

55,56

1,14E-05

0,021416

10_down

4

Cell motility/migration

     
 

- cell motility

87

44,83

1,72E-05

0,032183

11_down

5

Protein modification/assembly

     
 

- protein glycosylation

36

36,11

0,001102

2,041321

12_down

 

- protein modification

88

46,59

4,82E-05

0,090071

13_down

6

Metabolism

     
 

- nucleotide biosynthesis

84

41,67

5,39E-07

0,001009

14_down

7

Signaling

     
 

- response to calcium

40

40,00

2,91E-05

0,054402

15_down

 

- NF-kB

65

50,77

0,003016

5,494941

16_down

 

- phosphorylation

163

38,65

3E-07

0,000561

17_down

8

Transcription

     
 

- RNA splicing

135

36,30

3,48E-17

6,51E-14

18_down

  1. Subclasses are italicized, the cutoff value for differentially expressed genes was set to 1.2 fold change.