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Table 3 An ANOVA analysis of integrin pathway genes significantly differentially expressed between CAN/IFTA Banff 0 (no CAN/IFTA), Banff 1 (mild CAN/IFTA) and Banff 2,3 (moderate severe CAN/IFTA)

From: Genomic meta-analysis of growth factor and integrin pathways in chronic kidney transplant injury

Gene symbol Description Pairwise significance
Integrin subunits
ITGA1 integrin, alpha 1 (1, 2), (1, 3)
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (1, 3)
ITGA6 integrin, alpha 6 (1, 2), (1, 3), (2, 3)
ITGA9 integrin, alpha 9 (1, 2), (1, 3)
ITGAD integrin, alpha D (2, 1), (3, 1)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) (1, 2), (1, 3)
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (1, 2), (1, 3)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, ) (1, 2), (1, 3), (2, 3)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (1, 3)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (1, 3)
ITGB5 integrin, beta 5 (1, 2), (1, 3)
ITGB6 integrin, beta 6 (1, 2), (1, 3), (2, 3)
ITGB8 integrin, beta 8 (1, 2), (1, 3)
Integrin signaling pathway molecules associated with all grades of CAN
PTEN phosphatase and tensin homolog (1, 2), (1, 3), (2, 3)
PTENP1 phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1 (1, 2), (1, 3), (2, 3)
Integrin signaling pathway molecules associated with mild and moderate CAN but cannot distinguish mild from moderate CAN
ACTB actin, beta (1, 2), (1, 3)
ACTR2 ARP2 actin-related protein 2 homolog (yeast) (1, 2), (1, 3)
ACTR3 ARP3 actin-related protein 3 homolog (yeast) (1, 2), (1, 3)
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) (1, 2), (1, 3)
ARF4 ADP-ribosylation factor 4 (1, 2), (1, 3)
ARF6 ADP-ribosylation factor 6 (1, 2), (1, 3)
ARPC1A actin related protein 2/3 complex, subunit 1A, 41 kDa (1, 2), (1, 3)
ARPC2 actin related protein 2/3 complex, subunit 2, 34 kDa (1, 2), (1, 3)
ARPC4 actin related protein 2/3 complex, subunit 4, 20 kDa (2, 1), (3, 1)
ARPC5 actin related protein 2/3 complex, subunit 5, 16 kDa (1, 2), (1, 3)
CAPN10 calpain 10 (2, 1), (3, 1)
CAPN6 calpain 6 (2, 1), (3, 1)
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like (1, 2), (1, 3)
GRB2 growth factor receptor-bound protein 2 (1, 2), (1, 3)
KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (1, 2), (1, 3)
MYLK myosin, light chain kinase (1, 2), (1, 3)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog (1, 2), (1, 3)
PAK2 p21 (CDKN1A)-activated kinase 2 (1, 2), (1, 3)
PAK7 p21(CDKN1A)-activated kinase 7 (2, 1), (3, 1)
PIK3C2A phosphoinositide-3-kinase, class 2, alpha polypeptide (1, 2), (1, 3)
PIK3C3 phosphoinositide-3-kinase, class 3 (1, 2), (1, 3)
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide (1, 2), (1, 3)
PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide (1, 2), (1, 3)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) (1, 2), (1, 3)
PPP1CB protein phosphatase 1, catalytic subunit, beta isoform (1, 2), (1, 3)
PPP1CC protein phosphatase 1, catalytic subunit, gamma isoform (1, 2), (1, 3)
PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A (1, 2), (1, 3)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 (1, 2), (1, 3)
RRAS2 related RAS viral (r-ras) oncogene homolog 2 (1, 2), (1, 3)
SOS2 son of sevenless homolog 2 (Drosophila) (2, 1), (3, 1)
TLN1 talin 1 (2, 1), (3, 1)
TSPAN3 tetraspanin 3 (2, 1), (3, 1)
TTN titin (2, 1), (3, 1)
WIPF1 WAS/WASL interacting protein family, member 1 (1, 2), (1, 3)
Integrin signaling pathway molecules specifically associated with moderate CAN
ARF1 ADP-ribosylation factor 1 (1, 3)
ARPC1B actin related protein 2/3 complex, subunit 1B, 41 kDa (1, 3)
ARPC5L actin related protein 2/3 complex, subunit 5-like (1, 3)
CAPN7 calpain 7 (1, 3)
GIT1 G protein-coupled receptor kinase interactor 1 (3, 1)
ILK integrin-linked kinase (3, 1)
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) (1, 3)
MLCK MLCK protein (3, 1)
NCK2 NCK adaptor protein 2 (1, 3)
PAK3 p21 (CDKN1A)-activated kinase 3 (1, 3)
PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide (1, 3)
PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide (1, 3)
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide (3, 1)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) (1, 3)
PPP1CA protein phosphatase 1, catalytic subunit, alpha isoform (1, 3)
PPP1R12B protein phosphatase 1, regulatory (inhibitor) subunit 12B (3, 1)
SOS1 son of sevenless homolog 1 (Drosophila) (3, 1)
TSPAN4 tetraspanin 4 (1, 3)
TSPAN5 tetraspanin 5 (1, 3)
WASL Wiskott-Aldrich syndrome-like (3, 1)
  1. Numbers in brackets represent the pair-wise comparison significance (p < 0.005) where 1 = Banff 0, 2 = Banff 1 and 3 = Banff 2,3.