Table 20 Growth regulation, apoptosis and autophagy

p53 (p53)

Y

quaking related 54b; sam50 (qkr; sam50)

Y

p35 (p35)

N

held out wings (how)

Y

death executioner Bcl-2 homologue (debcl)

N

spinster (spin)

Y

homologous to bruce and Bombyx bir-superfamily domain protein - survivin-1 (bruce; survivin-1)

Y

death executioner caspase related to apopain/yama; decay; caspase 3 (decay)

N

bir-superfamily domain protein - inhibitor of apoptosis 1; thread (iap1; th; diap1)

Y

death caspase 1 (dcp-1)

N

bir-superfamily domain protein - inhibitor of apoptosis 2 (iap2; diap2)

Y

death related ced-3/nedd2-like protein; dredd/dcp-2 (dredd)

Y

ubiquitin conjugation enzyme E2; bendless (ubc13; ben)

Y

ice; drice; caspase-1 (in Bombyx mori) (ice)

Y

b-cell lymphoma protein 2 (bcl-2) protein - buffy (buffy)

Y

dronc; nedd2-like caspase (dronc; nc)

Y

autophagy-specific gene 1; serine/threonine-protein kinase unc-51 (atg1)

Y

dynamin related protein 1 (drp1)

Y

autophagy-specific gene 2 (atg2)

Y

similar to optic atrophy 1-like (opa1-like)

Y

autophagy-specific gene 3 (atg3; aut1)

Y

resistance to juvenile hormone; methoprene-tolerant (met)

Y

autophagy-specific gene 4 (atg4)

Y

deterin (det )

N

autophagy-specific gene 5 (atg5)

Y

tao-1 (tao-1)

Y

autophagy-specific gene 6; beclin-1 (atg6)

Y

melted (melt)

N

autophagy-specific gene 7 (atg7)

Y

midway (mdy)

N

autophagy-specific gene 8 (atg8)

Y

pita (pita)

Y

autophagy-specific gene 12 (atg12)

Y

plenty of sh3s (posh)

N

autophagy-specific gene 13 (atg13)

N

phosphoinositide-dependent kinase 1 dstpk61 (dstpk61)

Y

phosphotidylinositol 3 kinase 59f (pi3k59f; vps34)

Y

dream (strica; dream)

N

cell death activator-b (cide-b)

Y

target of rapamycin (tor)

Y

cell cycle and apoptosis regulatory protein 1 (ccar1)

Y

thor (thor)

N

longitudinals-lacking (lola)

Y

death associated molecule related to mch2; daydream (damm)

N

translationally controlled tumour protein (tctp)

Y

ecdysone-induced protein 28/29kD; methionine-s-sulfoxide reductase (Eip28/29; Eip71CD)

Y

apoptosis linked protein 2 (alg-2)

Y

modifier of rpr and grim, ubiquitously expressed; weak homology to ubiquitin-conjugating enzyme E2 D4 (morgue)

N