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Figure 1 | BMC Genomics

Figure 1

From: Global remodeling of nucleosome positions in C. elegans

Figure 1

Global distribution of nucleosomal reads. A) Two-dimensional histogram of read coverage in vivo. Chromosome III was divided into one thousand segments of equal length. The relative position of each segment is shown on the x-axis. The nucleosome read coverage, as measured in vivo by Gu & Fire [38], is shown on the y-axis. For each segment, a color-coded histogram shows the number of bases with a given read coverage. The black line shows mean read coverage in each segment. The range of the y-axis excludes the top 1.0% of bases with the highest read coverage. B) Two-dimensional histogram of read coverage in vitro. Same as (A), but with nucleosome read coverage data from the Hinc II in vitro assay. C) Dinucleotide frequencies. Chromosome III was divided into one thousand segments of equal length as in (A), and the dinucleotide composition in each segment was plotted against its relative genomic coordinate. A/T dinucleotides, composed only of A and T, are shown in red, G/C dinucleotides, composed only of G and C, are shown in blue, and mixed dinucleotides, including one A or T and one G or C nucleotide, are shown in pink. D) In vitro and in vivo nucleosome maps. Pearson correlations between read coverage profiles from each indicated experiment are plotted. For each comparison, a single correlation coefficient is calculated across all chromosomes.

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