Locus | Gene | Functional annotation or prediction | Commentsa | T | Min after acid shock | Adaptationb | |||
---|---|---|---|---|---|---|---|---|---|
 |  |  |  |  | 15 | 30 | 60 | 120 |  |
Induced after acid shock at both 25°C and 37°C. | |||||||||
lmo0137 |  | ABC transporter | Required for full virulence in mice [24] | 25°C | 4.0 | 5.0 | 5.8 | 9.5 | 0.8 |
37°C | 19.2 | 5.7 | 7.9 | 6.3 | n.a. | ||||
lmo0264 | inlE | InlE, internalin E | Required for full virulence in mice [25] | 25°C | 1.9 | 5.7 | 14.4 | 9.5 | 0.5 |
37°C | 5.7 | 6.5 | 4.2 | 2.2 | 1* | ||||
lmo0433 | inlA | InlA, internalin A | Required for host cell entry in vivo[26], PrfA-regulated [27]and σB[28] | 25°C | 1* | 4.6 | 6.5 | 4.4 | 1* |
37°C | 2.7 | 2.8 | 2.4 | 1* | 2.3 | ||||
lmo0434 | inlB | InlB, internalin B | Required for host cell entry in vivo[26], σB-regulated [28] | 25°C | 1* | 3.3 | 10.9 | 1* | 0.7 |
37°C | 3.8 | 7.1 | 4.0 | 1* | 1* | ||||
lmo0515 |  | Universal stress protein | Important for growth in vivo[29] | 25°C | 4.0 | 11.3 | 19.2 | 18.6 | 0.3 |
37°C | 9.3 | 10.4 | 10.3 | 4.1 | 1* | ||||
lmo0931 | lplA1 | Lipoate protein ligase A | Aborted replication in macrophages and in vivo[30] | 25°C | 1* | 1* | 1.7 | 2.3 | 1.5 |
37°C | 1.9 | 2.1 | 2.4 | 2.5 | 1* | ||||
lmo1295 | hfq | RNA-binding protein | Contributes to virulence [31] | 25°C | 1* | 2.1 | 3.4 | 2.8 | 0.6 |
37°C | 1* | 3.7 | 2.8 | 1.7 | 1* | ||||
lmo1377 | lisR | TCS response regulator | 25°C | 1* | 0.9 | 1.7 | 2.9 | 1* | |
37°C | 1* | 1* | 2.0 | 2.0 | 1.3 | ||||
lmo1580 |  | Universal stress protein | Important for growth in vivo[29] | 25°C | 3.5 | 7.1 | 7.7 | 7.6 | 1* |
37°C | 4.8 | 3.0 | 1.9 | 1* | 2.0 | ||||
lmo1683 | perR | Transcription regulator (Fur family), PerR in B. subtilis | Mutant is attenuated in mice [33] | 25°C | 1* | 2.6 | 3.5 | 5.4 | 1* |
37°C | 1.6 | 4.0 | 5.1 | 4.6 | 2.3 | ||||
lmo2067 | bsh c | Bile salt hydrolase | PrfA- [34] and σB-regulated [35], necessary for gastrointestinal persistence [36] and virulence [37] | 25°C | 3.1 | 7.1 | 9.1 | 7.0 | 0.4 |
37°C | (7.6) | (3.0) | (3.0) | (2.1) | (2.8) | ||||
lmo2157 | sepA | Hypothetical protein | Intracellularly up regulated [38, 39], deletion decreases virulence [40] | 25°C | 1* | 2.8 | 5.9 | 5.4 | 1* |
37°C | 3.2 | 5.0 | 4.3 | 1.6 | 1* | ||||
lmo2468 | clpP | ATP-dependent Clp protease, proteolytic subunit | Required for full virulence [41] and induced intracellularly [38] | 25°C | 1.4 | 1.9 | 4.1 | 6.4 | 1* |
37°C | 2.9 | 4.1 | 2.9 | 2.3 | 1.5 | ||||
lmo2515 | degU | Response regulator | Contributes to virulence [42] | 25°C | 0.9 | 0.9 | 2.0 | 3.0 | 1* |
37°C | 1* | 2.3 | 2.9 | 1.9 | 1* | ||||
lmo2673 |  | Universal stress protein | Important for growth in vivo[29] | 25°C | 1.9 | 6.7 | 13.8 | 12.6 | 0.6 |
37°C | 5.0 | 5.2 | 3.4 | 3.8 | 1* | ||||
Induced after acid shock at 25°C, but not at 37°C | |||||||||
lmo0641 | frvA | Fur-regulated virulence factor | A putative P-type ATPase required for virulence [43] | 25°C | 2.5 | 5.9 | 6.2 | 4.9 | 2.4 |
lmo0754 | btlB | Bile acid 7-α-dehydratase | Important for intestinal persistence [36] | 25°C | 1.9 | 2.0 | 1.9 | 1.5 | 1* |
lmo1773 | purB | Adenylosuccinate lyase | Mutants attenuated for systemic infection in mice [44] | 25°C | 1.0 | 0.9 | 2.4 | 1* | 1* |
Induced after acid shock at 37°C, but not at 25°C | |||||||||
lmo0153 | zinA | Zinc ABC transporter, Zn-binding | Contributes to full virulence in vivo[45] | 37°C | 1* | 1* | 1.85 | 2.28 | 1.38 |
lmo1829 | fbpA | Homologies to atypical fibronectin-binding proteins | Increases adherence, required for intestinal and liver colonization [46] | 37°C | 1* | 2.0 | 1.8 | 2.3 | 1* |