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Table 3 Age-associated changes in the levels of mouse circulating 5′ tRNA halves and the effects of CR on the age-associated changes

From: 5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

  Age   CR  
tRNA* Young control Old control Old CR FC p-value FC p-value
His-GTG  
chr4:82619623-82619694 797 2988 1554 3.8 3.1E-11 −2 6.8E-04
chr2:122377363-122377434 798 2994 1549 3.8 3.7E-11 −2 6.4E-04
chr3:96452495-96452566 307 1140 590 3.8 3.8E-11 −2 6.1E-04
chr2:122375494-122375565 808 2990 1533 3.8 3.9E-11 −2 5.0E-04
chr2:122377968-122378039 309 1163 600 3.8 4.2E-11 −2 6.6E-04
chr3:96458070-96458141 802 2993 1523 3.8 4.3E-11 −2 4.8E-04
chr3:96500366-96500437 796 2954 1524 3.8 4.5E-11 −2 5.9E-04
chr3:96410069-96410140 301 1148 590 3.9 2.0E-11 −2 5.5E-04
Arg-CCG  
chr11:107012866-107012938 1243 256 302 −5 9.9E-12 1.2 4.7E-01
Cys-GCA  
chr11:97798906-97798977 933 370 688 −2.6 2.5E-06 1.8 2.4E-03
chr11:97988246-97988317 928 376 700 −2.5 3.9E-06 1.8 2.2E-03
chr11:97988923-97988994 930 360 684 −2.6 1.3E-06 1.9 1.5E-03
Gly-GCC  
chr1:171074302-171074372 16868 3739 3807 −4.5 3.5E-14 −1 9.6E-01
chr1:171066631-171066701 16820 3730 3790 −4.5 4.3E-14 −1 9.6E-01
chr1:171081876-171081946 16779 3725 3788 −4.4 5.3E-14 −1 9.6E-01
Lys-CTT  
chr17:23533962-23534034 4175 1939 3286 −2.2 8.8E-06 1.7 3.7E-03
chr3:96428235-96428307 4215 1964 3353 −2.2 1.0E-05 1.7 3.3E-03
chr17:23547360-23547432 4098 1923 3272 −2.2 1.1E-05 1.7 3.4E-03
chr17:23535332-23535404 14085 6569 11132 −2.2 1.2E-05 1.7 4.1E-03
chr13:23436340-23436412 4181 1962 3321 −2.2 1.2E-05 1.7 3.9E-03
chr3:96499512-96499584 13865 6507 11017 −2.2 1.3E-05 1.7 3.9E-03
chr11:48833883-48833955 13905 6539 11051 −2.2 1.4E-05 1.7 4.1E-03
Val-AAC  
chr13:23401073-23401145 1247 451 814 −2.8 3.3E-07 1.8 4.1E-03
chr13:23413248-23413320 1246 467 836 −2.7 5.4E-07 1.8 4.0E-03
  1. *tRNA isoacceptor identity with corresponding genomic positions of the tRNA genes in the mouse mm10 genome.
  2. Average tRNA read count for the indicated experimental group reported as counts per million (cpm) reads in the sequenced library from the indicated experimental group.
  3. Fold change calculated by EdgeR from pairwise comparisons between the young and old control groups for the age effect, or between the old control and old CR groups for the CR effect.