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Table 3 Age-associated changes in the levels of mouse circulating 5′ tRNA halves and the effects of CR on the age-associated changes

From: 5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

 

Age

 

CR

 

tRNA*

Young control †

Old control†

Old CR†

FC‡

p-value

FC‡

p-value

His-GTG

 

chr4:82619623-82619694

797

2988

1554

3.8

3.1E-11

−2

6.8E-04

chr2:122377363-122377434

798

2994

1549

3.8

3.7E-11

−2

6.4E-04

chr3:96452495-96452566

307

1140

590

3.8

3.8E-11

−2

6.1E-04

chr2:122375494-122375565

808

2990

1533

3.8

3.9E-11

−2

5.0E-04

chr2:122377968-122378039

309

1163

600

3.8

4.2E-11

−2

6.6E-04

chr3:96458070-96458141

802

2993

1523

3.8

4.3E-11

−2

4.8E-04

chr3:96500366-96500437

796

2954

1524

3.8

4.5E-11

−2

5.9E-04

chr3:96410069-96410140

301

1148

590

3.9

2.0E-11

−2

5.5E-04

Arg-CCG

 

chr11:107012866-107012938

1243

256

302

−5

9.9E-12

1.2

4.7E-01

Cys-GCA

 

chr11:97798906-97798977

933

370

688

−2.6

2.5E-06

1.8

2.4E-03

chr11:97988246-97988317

928

376

700

−2.5

3.9E-06

1.8

2.2E-03

chr11:97988923-97988994

930

360

684

−2.6

1.3E-06

1.9

1.5E-03

Gly-GCC

 

chr1:171074302-171074372

16868

3739

3807

−4.5

3.5E-14

−1

9.6E-01

chr1:171066631-171066701

16820

3730

3790

−4.5

4.3E-14

−1

9.6E-01

chr1:171081876-171081946

16779

3725

3788

−4.4

5.3E-14

−1

9.6E-01

Lys-CTT

 

chr17:23533962-23534034

4175

1939

3286

−2.2

8.8E-06

1.7

3.7E-03

chr3:96428235-96428307

4215

1964

3353

−2.2

1.0E-05

1.7

3.3E-03

chr17:23547360-23547432

4098

1923

3272

−2.2

1.1E-05

1.7

3.4E-03

chr17:23535332-23535404

14085

6569

11132

−2.2

1.2E-05

1.7

4.1E-03

chr13:23436340-23436412

4181

1962

3321

−2.2

1.2E-05

1.7

3.9E-03

chr3:96499512-96499584

13865

6507

11017

−2.2

1.3E-05

1.7

3.9E-03

chr11:48833883-48833955

13905

6539

11051

−2.2

1.4E-05

1.7

4.1E-03

Val-AAC

 

chr13:23401073-23401145

1247

451

814

−2.8

3.3E-07

1.8

4.1E-03

chr13:23413248-23413320

1246

467

836

−2.7

5.4E-07

1.8

4.0E-03

  1. *tRNA isoacceptor identity with corresponding genomic positions of the tRNA genes in the mouse mm10 genome.
  2. †Average tRNA read count for the indicated experimental group reported as counts per million (cpm) reads in the sequenced library from the indicated experimental group.
  3. ‡Fold change calculated by EdgeR from pairwise comparisons between the young and old control groups for the age effect, or between the old control and old CR groups for the CR effect.
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BMC Genomics

ISSN: 1471-2164

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