Intra-species backbone stability analysis. A Data used for model fitting and the prediction and confidence intervals (continuous and dashed red lines) of the best model (R o c h a+3p in the text). In the main plot, the phylogenetic distance is in log scale for clarity (see inset for original values). B Intra-species comparisons. The endosymbionts Sulcia and Buchnera have very stable genomes, but the latter has more variability in gene order. C Residuals with respect to the best model for each strain. Strains more than 2 standard deviations from the average residual within a species are highlighted. D Color code for species. Species abbreviations are color coded in the following way: red, pathogens; underlined red, species comprising both pathogens and non-pathogens; green, plant pathogens; black, non-pathogens.