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Figure 2 | BMC Genomics

Figure 2

From: Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains

Figure 2

ROC plots of the PrD recovery and bootstrapping assays. The scoring histogram distributions of the negative and positive datasets were processed and the true positive rate (TPR) was plotted against the false positive rate (FPR) in a tryout in which the known PrDs –i.e. positives in all four experimental tests [38]– are picked up from a test dataset of non prions –i.e. negatives in all four experimental tests [38]. In red we show the plot obtained using our model which has an area under the curve (AUC) of 0.90. We also include the result of a bootstrap assay in which the 18 prions used as the training set were resampled 106 times forming partial training sets of 9 prions and generating positive test sets for the ROC plot analysis of the rest 9 prions. One million ROC plots were generated always using the same negative set and the average ROC curve was calculated (shown in blue), the area under the curve (AUC) is 0.85.

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