Figure 4

Precision-recall plots for the comparison of PrD and non-prionogenic sequence distributions. For each one of the three negative additional datasets including proteins from Uniprot, Disprot and the PDB we follow the evolution of the classifier’s Precision to correctly make a positive mapping of known PrD segments from a pool of non-prionogenic sequences. These values are plotted against the TPR –i.e. recall– of the corresponding classification step. The ratio between the number of instances in each positive and negative distribution is also shown.