Comparative gene expression between two yeast species

BMC Genomics

Table 1 Mis-annotated genes identified by LNS

Gene	Old ortholog	New ortholog	LNS	Comments
*620.38*	*YOR101W*	*YOR089C*	−0.379	Blast e-value to *VPS21* is 1e-92. Blast to *RAS1* is 11th on list.
*576.11*	*YGL157W*	*YGL039W*	0.184	Note similar synteny conflict with *674.45* . This gene is second best blast, e-value 1e-160.
*674.45*	*YGL039W*	*YGL157W*	−0.077	Synteny preserved by change, new gene is best blast hit with e-value 3e-146. Note similar problem with *576.11* .
*635.17*	*YOR267C*	*YOR233W*	−0.633	Synteny preserved by change. *YOR233W* is best blast hit with e-value 0.
*636.13*	*YPR119W*	*YPR120C*	−0.03
(cell cycle)	Best hit with *CLB5 (YPR120C)* .

Ortholog pairings were initially taken from the original genome annotation [7]. Several mis-pairs were identified by their low global or condition-specific LNS.

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