Comparative gene expression between two yeast species

BMC Genomics

Table 2 Paired datasets of S. bayanus and S. cerevisiae for condition-specific LNS calculation

S. bayanusdataset	S. cerevisiaedataset	Number of diverged genes (lower than average of randomization, cutoff)	P-value	Median LNS
MMS	[51]	1498 (−0.02515)	1.67E-153	0.2348
Heat shock	[52]	1032 (−0.00467)	4.25E-271	0.2259
Sorbitol	[52]	1330 (0.00561)	3.35E-163	0.1678
Uracil	[53]	1590 (0.001)	5.75443E-82	0.1031
Rapamycin	[54]	1896 (−0.0101)	1.63545E-33	0.07464
Alpha factor	[55]	1438 (−0.006)	5.5186E-102	0.0848
Sporulation	[56]	922 (0.0038)	3.7792E-288	0.08923
Cell cycle	[57]	1124 (0.0047)	1.7278E-226	0.09546
Diauxic shift	[58]	947 (0.00656)	1.1322E-257	0.3741

We permuted gene-gene correlations to simulate the LNS distribution of a randomized network. The numbers of genes below the average LNS for these random networks were counted. We also calculated the p-value by randomizing the matches between orthologs to simulate non-conservation. The average LNS for each matched dataset pair was calculated.

ISSN: 1471-2164