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Figure 7 | BMC Genomics

Figure 7

From: Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver

Figure 7

Association of CREB binding sites with additional transcription factor occupancy at fasting-responsive genes. CREB sites were separated into 3 groups: 285 sites associated with genes up-regulated in fasted state (red), 321 sites associated with genes down-regulated in fasted state (green), 6,018 sites associated with genes that did not change (gray). A-F) Average ChIP-seq profiles around each group of CREB binding sites are shown for CREB (A), CEBPB (B), NR3C1/GR (C), FOXA2 (D), PPARA (E), and CTCF (F). Corresponding distributions of peak heights are shown as box plots in Additional file 1: Figure S7 and tabulated in Additional file 3. G) Percentage of sites in each group containing the indicated motifs within +/− 250 bp of peak center. *p-value < 0.001 by Fisher’s exact test compared to gray bar.

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