Stronger activation of defense related genes or gene groups correlates with successful tuber resistance against P. infestans . Tubers of ‘Russet Burbank’ (WT) and SP2211 (+RB) were inoculated with P. infestans and water. We compared the RNA-seq FPKM counts for WT and +RB using all 39,031 gene models included in the Potato Genome Sequencing Consortium (PGSC) v3 dataset (i.e., all genes were included, regardless of whether or not a given gene was DE). Genes were grouped into ontology bins using a Mapman mapping file. Each column represents a comparison between the two genotypes at a defined time point post inoculation, as indicated. Bins in blue are transcribed at higher levels in WT than in +RB; bins in red are transcribed at higher levels in +RB than in WT; bins in white did not significantly differ in transcript levels between WT and +RB. Results indicate that faster and stronger activation of defense bins, most notably biotic stress response and receptor kinase bins, occurred in tubers of the tuber late blight resistant +RB line.