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Table 1 List of potentially novel and novel lipid associated complexes implicated in liver cancer

From: Enhancing the utility of Proteomics Signature Profiling (PSP) with Pathway Derived Subnets (PDSs), performance analysis and specialised ontologies

Novelty CORUM ID Complex name Function Lipid involvement
PN 1096 SNX and PDGF receptor complex reported to be involved in transport and transmembrane signal transduction lipid involvement yes
PN 1104 Transferrin receptor complex reported involved in transport and receptor mediated endocytosis lipid association yes
PN 563 Complex V; F1F0 ATPase energy production, mitochondrial processes, particularly in heart muscle lipid involvement yes
PN 654 BLOC1-BLOC2 complex transport and targeting lipid involvement potentially novel
PN 142 CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) signaling, protein fate lipid involvement yes
PN 652 AP3-Bloc1-complex transport lipid involvement yes
PN 657 Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) protein targeting and transport lipid involvement yes
PN 2837 Profilin 1 complex cytoskeleton organisation, endocytosis, potential metastasis involvement lipid involvement yes
PN 1060 Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) transport lipid association yes
N 280 HMGB1-HMGB2-HSC70-ERP60-GAPDH complex DNA repair, nucleic acid binding, response to stress and DNA damage stimulus);high cancer association lipid involvement not immediately decipherable
N 312 Cell cycle kinase complex CDK4l cell cycle control, cancer association yes lipid involvement not immediately decipherable
N 247 RalBP1-CCNB1-AP2A-NUMB-EPN1 complex cell cycle control, endocytosis lipid involvement not immediately decipherable
N 5230 CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex Signaling, cancer association yes lipid involvement not immediately decipherable
N 311 Cell cycle kinase complex CDK2 cell cycle control, cancer association yes lipid involvement not immediately decipherable
N 5423 HSP70-BAG5-PARK2 complex protein folding and stabilisation lipid involvement not immediately decipherable
N 2390 CD98-LAT2-ITGB1 complex cell adhesion, may define cell polarity which in turn has to do with invasiveness lipid involvement not immediately decipherable
  1. *PN – potentially novel, N – novel.
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