Table 1 List of potentially novel and novel lipid associated complexes implicated in liver cancer
Novelty | CORUM ID | Complex name | Function | Lipid involvement |
|---|---|---|---|---|
PN | 1096 | SNX and PDGF receptor complex | reported to be involved in transport and transmembrane signal transduction | lipid involvement yes |
PN | 1104 | Transferrin receptor complex | reported involved in transport and receptor mediated endocytosis | lipid association yes |
PN | 563 | Complex V; F1F0 ATPase | energy production, mitochondrial processes, particularly in heart muscle | lipid involvement yes |
PN | 654 | BLOC1-BLOC2 complex | transport and targeting | lipid involvement potentially novel |
PN | 142 | CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) | signaling, protein fate | lipid involvement yes |
PN | 652 | AP3-Bloc1-complex | transport | lipid involvement yes |
PN | 657 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) | protein targeting and transport | lipid involvement yes |
PN | 2837 | Profilin 1 complex | cytoskeleton organisation, endocytosis, potential metastasis involvement | lipid involvement yes |
PN | 1060 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) | transport | lipid association yes |
N | 280 | HMGB1-HMGB2-HSC70-ERP60-GAPDH complex | DNA repair, nucleic acid binding, response to stress and DNA damage stimulus);high cancer association | lipid involvement not immediately decipherable |
N | 312 | Cell cycle kinase complex CDK4l | cell cycle control, cancer association yes | lipid involvement not immediately decipherable |
N | 247 | RalBP1-CCNB1-AP2A-NUMB-EPN1 complex | cell cycle control, endocytosis | lipid involvement not immediately decipherable |
N | 5230 | CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex | Signaling, cancer association yes | lipid involvement not immediately decipherable |
N | 311 | Cell cycle kinase complex CDK2 | cell cycle control, cancer association yes | lipid involvement not immediately decipherable |
N | 5423 | HSP70-BAG5-PARK2 complex | protein folding and stabilisation | lipid involvement not immediately decipherable |
N | 2390 | CD98-LAT2-ITGB1 complex | cell adhesion, may define cell polarity which in turn has to do with invasiveness | lipid involvement not immediately decipherable |