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Table 5 GO molecular functions representative of top five overrepresented functional annotation clusters among genes overexpressed in embryos versus somatic cells at P < 0.001 and 10 FC

From: RNA-seq analysis of single bovine blastocysts

Molecular process Gene count P value Genes
Transcription factor activity 33 0.002 HNF1B, CDX2, SOX2, DMRTA2, TCF7L1, CITED1, MSX2, GATA2, POU5F1, LHX2, HOXC5, SPIC, LHX8, PITX1, KLF5, NANOG, GSC, TBX3, RCOR2, ESRRB, OTX2, ESRRG, TEAD3, FOXR1, MYCN, HOXB4, GCM1, HNF4A, LASS3, FOXG1, DLX4, HEYL, HOXB9
ATPase activity, coupled 14 0.003 RECQL4, ATP1B3, ATP1B2, DDX4, DDX28, DDX3Y, ABCC4, ATP6V1G3, ABCC2, ATP6V0A4, KATNAL2, ABCC5, ATP7B, MYH10
Transmembrane receptor protein tyrosine kinase activity 7 0.002 IGSF10, TYRO3, FGFR4, FGFR3, PTK7, PDGFRA, KIT
Folic acid binding 3 0.028 FOLR1, SLC19A3, GNMT
Helicase activity 8 0.037 RECQL4, DDX28, PIF1, TDRD9, DDX3Y, MCM4, RAD54L, DDX4