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Table 1 Significantly overrepresented functional annotations describing sleep-repressed transcripts in the heart

From: Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues

 

Cluster 1

   

Category

Term

P-Value

Fold Enrichment

FDR(%)

SP_PIR_KEYWORDS

Chaperone

7.39E-09

4.992

1.0E-05

SP_PIR_KEYWORDS

Stress response

3.39E-08

9.446

4.6E-05

GOTERM_BP_FAT

GO:0006457 Protein folding

5.87E-05

3.908

1.0E-01

 

Cluster 2

   

Category

Term

P-Value

Fold Enrichment

FDR(%)

GOTERM_BP_FAT

GO:0043066 Negative regulation of apoptosis

1.13E-06

3.400

0.00195

GOTERM_BP_FAT

GO:0043069 Negative regulation of programmed cell death

1.61E-06

3.330

0.00277

GOTERM_BP_FAT

GO:0060548 Negative regulation of cell death

1.73E-06

3.316

0.00298

GOTERM_BP_FAT

GO:0042981 Regulation of apoptosis

4.09E-05

2.173

0.07051

GOTERM_BP_FAT

GO:0043067 Regulation of programmed cell death

5.27E-05

2.145

0.09073

GOTERM_BP_FAT

GO:0010941 Regulation of cell death

5.85E-05

2.133

0.10074

GOTERM_BP_FAT

GO:0006916 Anti-apoptosis

2.01E-04

4.361

0.34531

 

Cluster 3

   

Category

Term

P-Value

Fold Enrichment

FDR(%)

GOTERM_BP_FAT

GO:0022604 Regulation of cell morphogenesis

1.79E-05

4.725

0.03093

 

Cluster 4

   

Category

Term

P-Value

Fold Enrichment

FDR(%)

SP_PIR_KEYWORDS

Nucleosome core

7.18E-04

6.358

0.97486

  1. Sleep repressed transcripts demonstrate both significantly reduced expression in sleep as compared to sleep deprivation (FDR < 1%) and a decreasing expression as spontaneous sleep progresses (FDR <1%). Overrepresented functional annotations describing this group of transcripts that met a FDR cutoff of 5% are shown. Clusters describe overlapping gene annotations as determined by the DAVID functional clustering feature.
  2. SP_PIR: Swiss-Prot Protein Information Resource; GOTERM_BP_FAT: Gene ontology term Biological process; KEEG: Kyoto Encyclopedia of Genes and Genomes.