Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues

BMC Genomics

Table 2 Significantly overrepresented functional annotations describing sleep-repressed transcripts in the lung

	Cluster 1
Category	Term	P-Value	Fold Enrichment	FDR(%)
SP_PIR_KEYWORDS	Chaperone	4.07E-15	10.133	5.40E-12
SP_PIR_KEYWORDS	Stress response	4.51E-14	21.351	5.94E-11
SP_PIR_KEYWORDS	Molecular chaperone	4.92E-12	44.118	6.46E-09
GOTERM_BP_FAT	GO:0006457 Protein folding	7.28E-11	8.835	1.18E-07
	Cluster 2
Category	Term	P-Value	Fold Enrichment	FDR(%)
SP_PIR_KEYWORDS	Molecular chaperone	4.92E-12	44.118	6.46E-09
SP_PIR_KEYWORDS	Stress-induced protein	0.001235	51.471	1.611722
SP_PIR_KEYWORDS	Heat shock	0.001235	51.47	1.611722
	Cluster 3
Category	Term	P-Value	Fold Enrichment	FDR(%)
SP_PIR_KEYWORDS	Isomerase	0.00167	4.65	2.18
	Cluster 4
Category	Term	P-Value	Fold Enrichment	FDR(%)
KEGG_PATHWAY	NOD-like receptor signaling pathway	2.78E-04	7.537	0.30520
	Cluster 5
Category	Term	P-Value	Fold Enrichment	FDR(%)
KEGG_PATHWAY	Antigen processing and presentation	3.99E-05	6.840	0.04383

Sleep repressed transcripts demonstrate both significantly reduced expression in sleep as compared to sleep deprivation (FDR < 1%) and a decreasing expression as spontaneous sleep progresses (FDR <1%). Overrepresented functional annotations describing this group of transcripts that met a FDR cutoff of 5% are shown. Clusters describe overlapping gene annotations as determined by the DAVID functional clustering feature.
SP_PIR: Swiss-Prot Protein Information Resource; GOTERM_BP_FAT: Gene ontology term Biological process; KEEG: Kyoto Encyclopedia of Genes and Genomes.

ISSN: 1471-2164