Child | Parent 1 | Parent 2 BAF |
|---|
AB | BB | ↑ |
AB | AA | ↓ |
AA | AA, AB, NC | ↑ |
BB | AB, BB, NC | ↓ |
- The POD method can also be employed to detect parental abnormalities. Given specific genotype combinations between a parent and child, when the other parent’s BAF value is an outlier of the normal BAF distribution, it may be indicative of a departure from expected biallelic inheritance. The ↑ symbol indicates an unexpected elevation of the BAF value (unexpectedly high proportion of B alleles). The ↓ symbol indicates an unexpected depression of the BAF value (unexpectedly low proportion of B alleles).
