TY - JOUR AU - Llorens, Franc AU - Hummel, Manuela AU - Pantano, Lorena AU - Pastor, Xavier AU - Vivancos, Ana AU - Castillo, Ester AU - Mattlin, Heidi AU - Ferrer, Anna AU - Ingham, Matthew AU - Noguera, Marc AU - Kofler, Robert AU - Dohm, Juliane C. AU - Pluvinet, Raquel AU - Bayés, Mònica AU - Himmelbauer, Heinz AU - del Rio, José Antonio AU - Martí, Eulàlia AU - Sumoy, Lauro PY - 2013 DA - 2013/06/01 TI - Microarray and deep sequencing cross-platform analysis of the mirRNome and isomiR variation in response to epidermal growth factor JO - BMC Genomics SP - 371 VL - 14 IS - 1 AB - Epidermal Growth Factor (EGF) plays an important function in the regulation of cell growth, proliferation, and differentiation by binding to its receptor (EGFR) and providing cancer cells with increased survival responsiveness. Signal transduction carried out by EGF has been extensively studied at both transcriptional and post-transcriptional levels. Little is known about the involvement of microRNAs (miRNAs) in the EGF signaling pathway. miRNAs have emerged as major players in the complex networks of gene regulation, and cancer miRNA expression studies have evidenced a direct involvement of miRNAs in cancer progression. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-14-371 DO - 10.1186/1471-2164-14-371 ID - Llorens2013 ER -