Figure 5

Significant enrichment in mRNAs down-regulated by EGF among experimentally validated targets of EGF-dependent miRNAs. Plot comparing the percentage of observed versus randomly expected mRNAs regulated by EGF that are known experimentally validated targets of the nine miRNAs shown to be regulated by EGF in this study. Actual % (gray): experimentally observed; Simulated % (black); result of random permutations; DW 6 h: down regulated mRNAs at 6 h; UP 6 h, up-regulated mRNAs at 6 h. Two randomization tests were performed: choosing as many (n = 8) miRNAs as those found regulated (random miRNAs) and looking at their targets, or choosing as many target mRNAs (n = 168) among the experimentally validated targets of the entire miRTarBase.