Table 3 Genes that activate unique pathways specific to radiation types in normal HEBC3KT
Gene | Adjusted p-value | Radiation | Fold change | Specific radiation quality | IPA unique pathway | Gene interaction | |||
|---|---|---|---|---|---|---|---|---|---|
1 hr | 4 hr | 12 hr | 24 hr | ||||||
THBS1 | 0.0005 | γ-ray | −1.1 | 1.0 | 1.1 | 1.4 | γ-ray | Inhibition of angiogenesis by TSP1 | Phosphorylation of CD36 and FYN, subsequently activates p38, p53 and caspase 3 to promote apoptosis. |
>0.01 | Si | 1.1 | 1.2 | 1.2 | −1.1 | ||||
>0.01 | Fe | 1.1 | 1.2 | −1.1 | −1.0 | ||||
SH3GL3 | 0.0001 | γ-ray | −1.3 | 1.1 | −1.1 | 1.2 | γ-ray | Mechanism of viral exit from host cells | Phosphorylation of ALIX, whose activation blocks apoptosis |
>0.01 | Si | 1.2 | −1.0 | 1.3 | 1.2 | ||||
>0.01 | Fe | 1.0 | −1.2 | −1.1 | 1.0 | ||||
APH1B | >0.01 | γ-ray | 1.2 | 1.1 | 1.3 | −1.0 | Fe | Notch signaling | Cleaves Notch C-terminal fragment, release the active form NCID and translocate to nucleus |
>0.01 | Si | 1.0 | 1.2 | −1.1 | 1.2 | ||||
0.00002 | Fe | 1.0 | −1.3 | 1.1 | 1.1 | ||||
BLNK | >0.01 | γ-ray | −1.2 | 1.1 | −1.2 | 1.2 | Si | Phospholipase C signaling | BLNK, PLD1 and PLD3 are upstream molecules that activate PLC-β and PLC-γ. PLC-γ subsequently activates PKC and the latter activates ERK1/2 and NF-κB pathways. |
0.00002 | Si | −1.3 | 1.2 | 1.1 | 1.5 | ||||
>0.01 | Fe | −1.0 | 1.1 | 1.1 | 1.1 | ||||
PLD1 | >0.01 | γ-ray | −1.0 | −1.2 | −1.2 | 1.2 | Si | ||
0.0002 | Si | −1.2 | 1.1 | 1.4 | −1.0 | ||||
>0.01 | Fe | 1.0 | 1.2 | 1.1 | −1.1 | ||||
PLD3 | >0.01 | γ-ray | −1.2 | −1.1 | 1.2 | 1.0 | Si | ||
0.0002 | Si | −1.1 | 1.2 | 1.3 | 1.6 | ||||
>0.01 | Fe | −1.2 | −1.2 | 1.1 | −1.3 | ||||