Figure 2

sAPPα regulates gene expression in a temporally specific manner. (A) Histogram showing that the majority of genes identified as differentially expressed following exposure of organotypic hippocampal slice cultures to sAPPα were upregulated at 15 min, while the majority were downregulated at 2 h and 24 h. Differentially expressed genes were identified using a dual selection criteria (±1.15 fold change; p < 0.05), see text for further details. (B) Venn diagram showing that the three datasets involved distinct gene sets.