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Table 4 sAPPα regulates genes linked to amyloidtoxicity and Alzheimer’s disease

From: Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus

Gene symbol Gene title Fold change Functional effects References
   15 min 2 h 24 h   
Fish Adapter protein TKS5 1.2 - - Mediates the neurotoxic effect of amyloid-β [35]
Frp2 Formyl peptide receptor 2 - - −1.4 Activated by amyloid-β, may mediate inflammation seen in Alzheimer's disease [36]
Gapdh Glyceraldehyde-3-phosphate dehydrogenase 1.2 - −1.5 May interact with neurodegenerative disease-associated proteins [37]
Ppif Peptidylprolyl isomerase F - - −1.4 An absence of this gene is neuroprotective against amyloid-β induced cell death [38]
Tnf Tumour necrosis factor 1.4 - - Protects neurons against amyloid-β induced toxicity [39]
Ttr Transthyretin - −2.8 - Binds amyloid-β and prevents fibril formation in vitro [40]
Ccl-3 Chemokine (C-C motif) ligand 3 - 1.3 - Protein levels are increased in Alzheimer's disease [41]
Fos FBJ murine osteosarcoma viral oncogene homolog 1.3 - - Gene expression is increased in Alzheimer's disease [42]
Ilib Interleulin 1-beta - 1.3 - Protein levels are increased in Alzheimer's disease [43]
MiR-9 MicroRNA- 9 1.2 −1.2 - Expression is reduced in Alzheimer's disease [44]
MiR-29 MicroRNA-29 1.3 - - Regulator of BACE1 and decreased in Alzheimer's disease [45]
Otc Ornithine transcarbamylase −1.2 - - Gene expression is increased in Alzheimer's disease [46]
Rgsl2 Regulator of G-protein signaling like 2 - 1.2 - Gene associated with late onset Alzheimer's disease [47]
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