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Table 4 sAPPα regulates genes linked to amyloid-ß toxicity and Alzheimer’s disease

From: Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus

Gene symbol

Gene title

Fold change

Functional effects

References

  

15 min

2 h

24 h

  

Fish

Adapter protein TKS5

1.2

-

-

Mediates the neurotoxic effect of amyloid-β

[35]

Frp2

Formyl peptide receptor 2

-

-

−1.4

Activated by amyloid-β, may mediate inflammation seen in Alzheimer's disease

[36]

Gapdh

Glyceraldehyde-3-phosphate dehydrogenase

1.2

-

−1.5

May interact with neurodegenerative disease-associated proteins

[37]

Ppif

Peptidylprolyl isomerase F

-

-

−1.4

An absence of this gene is neuroprotective against amyloid-β induced cell death

[38]

Tnf

Tumour necrosis factor

1.4

-

-

Protects neurons against amyloid-β induced toxicity

[39]

Ttr

Transthyretin

-

−2.8

-

Binds amyloid-β and prevents fibril formation in vitro

[40]

Ccl-3

Chemokine (C-C motif) ligand 3

-

1.3

-

Protein levels are increased in Alzheimer's disease

[41]

Fos

FBJ murine osteosarcoma viral oncogene homolog

1.3

-

-

Gene expression is increased in Alzheimer's disease

[42]

Ilib

Interleulin 1-beta

-

1.3

-

Protein levels are increased in Alzheimer's disease

[43]

MiR-9

MicroRNA- 9

1.2

−1.2

-

Expression is reduced in Alzheimer's disease

[44]

MiR-29

MicroRNA-29

1.3

-

-

Regulator of BACE1 and decreased in Alzheimer's disease

[45]

Otc

Ornithine transcarbamylase

−1.2

-

-

Gene expression is increased in Alzheimer's disease

[46]

Rgsl2

Regulator of G-protein signaling like 2

-

1.2

-

Gene associated with late onset Alzheimer's disease

[47]