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Table 1 Differential expression of cell adhesion molecules

From: Transcriptional adaptation of pneumococci and human pharyngeal cells in the presence of a virus infection

A. Genes up-regulated by infection with HPIV3

   

Fold change

GB#

Gene name

Gene symbol

HPIV3-infected/mock-infected

RSV-infected/mock-infected

TIGR4-infected/mock-infected

HPIV3-TIGR4-infected/mock-infected

RSV-TIGR4-infected/mock-infected

AA406020

ISG15 ubiquitin-like modifier

ISG15

23.80

1.10

1.05

24.76

1.15

AA456886

Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78

MX1

23.68

1.11

1.04

16.12

1.12

AA286908

Myxovirus (influenza virus) resistance 2

MX2

13.84

1.06

1.05

12.35

1.04

T95113

Radical S-adenosyl methionine domain containing 2

RSAD2

11.72

0.90

1.11

4.49

1.39

AA126958

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

DDX58

11.55

1.16

0.88

9.94

0.96

AA419251

Interferon induced transmembrane protein 1 (9-27)

IFITM1

7.32

0.96

0.99

5.88

0.76

AA421603

SAM domain and HD domain 1

SAMHD1

5.67

0.96

0.89

4.80

0.86

AI245550

Phospholipid scramblase 1

PLSCR1

5.00

0.91

0.95

3.36

1.11

AA995904

TCF3 (E2A) fusion partner

TFPT

4.05

1.35

1.05

4.12

0.91

AA827287

Interferon-induced protein 35

IFI35

3.85

1.10

0.95

3.40

1.00

H54629

Tumor necrosis factor (ligand) superfamily, member 10

TNFSF10

3.64

NA

1.18

4.32

NA

AA862371

Interferon induced transmembrane protein 2 (1-8D)

IFITM2

3.37

0.85

0.92

2.18

0.93

AA877255

Interferon regulatory factor 7

IRF7

3.25

X

1.06

2.13

0.71

R07870

Baculoviral IAP repeat-containing 3; inhibitor of apoptosis protein

-

3.09

2.09

1.20

1.79

1.60

AI038270

Eukaryotic translation initiation factor 2-alpha kinase 2

EIF2AK2

2.91

1.11

0.99

1.56

1.04

AA479795

Interferon stimulated exonuclease gene 20kda

ISG20

2.91

NA

1.10

2.29

NA

N67034

Interferon-induced protein 44-like

IFI44L

2.87

1.01

1.05

2.90

0.94

AA418724

Zinc finger CCCH-type, antiviral 1

ZC3HAV1

2.82

1.53

1.31

1.77

1.49

N75384

Peroxisome proliferator-activated receptor gamma, coactivator 1 beta

PPARGC1B

2.45

0.78

0.94

NA

0.58

W37864

Phosphatase and tensin homolog

PTEN

2.43

0.90

0.93

1.05

0.78

H17861

Ring finger protein 213

RNF213

2.26

1.05

1.03

1.14

1.02

AA983252

Signal transducer and activator of transcription 2, 113kda

STAT2

2.23

X

1.12

1.53

NA

R70479

Tumor necrosis factor, alpha-induced protein 3

TNFAIP3

2.17

0.75

1.03

NA

0.73

AA128561

Collagen, type XVII, alpha 1

COL17A1

1.95

1.11

1.99

1.16

1.15

AI016022

NLR family, CARD domain containing 5

NLRC5

1.93

X

X

X

0.94

N70463

B-cell translocation gene 1, anti-proliferative

BTG1

1.90

1.43

1.13

NA

1.39

H61758

ELK4, ETS-domain protein (SRF accessory protein 1)

ELK4

1.86

0.80

0.87

NA

1.03

R33456

Desmoplakin

DSP

1.82

1.03

0.88

1.18

0.86

AI085559

Arylacetamide deacetylase-like 1

AADACL1

1.80

1.64

X

1.69

1.79

AA609992

Dehydrogenase/reductase (SDR family) member 9

DHRS9

1.78

1.45

0.95

1.09

1.50

AA136060

Polycomb group ring finger 5

PCGF5

1.74

0.99

0.96

1.21

0.82

AI364513

Scavenger receptor class B, member 2

SCARB2

1.72

1.06

NA

NA

0.97

AA491191

Interferon, gamma-inducible protein 16

IFI16

1.72

1.38

0.94

0.97

1.99

AA451844

Microtubule associated monoxygenase, calponin and LIM domain containing 2

MICAL2

1.70

0.91

0.91

X

0.79

R92801

CD47 molecule

CD47

1.68

1.57

1.01

1.16

1.64

R93911

Glycogen synthase kinase 3 beta

GSK3B

1.68

1.29

NA

NA

1.32

AA776304

Pleckstrin 2

PLEK2

1.67

0.97

NA

1.81

1.08

AA490894

Endoplasmic reticulum aminopeptidase 1

ERAP1

1.67

1.19

0.87

X

1.25

AA777854

Ring finger protein 12

RNF12

1.67

0.85

0.99

NA

0.92

AA040699

ELK3, ETS-domain protein (SRF accessory protein 2)

ELK3

1.65

0.99

0.91

X

0.86

H95362

Claudin 1

CLDN1

1.64

0.83

NA

1.26

1.20

AA411757

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

CEACAM1

1.63

X

NA

1.41

0.51

AA284668

Plasminogen activator, urokinase

PLAU

1.63

1.15

1.27

X

1.25

AA135422

CCR4-NOT transcription complex, subunit 1

CNOT1

1.63

0.99

0.89

1.04

1.05

AI049712

Epidermal growth factor receptor

EGFR

1.62

1.00

0.91

1.13

0.96

N70848

Ring finger protein 141

RNF141

1.58

1.11

0.94

1.08

0.90

AA005112

LIM domain 7

LMO7

1.58

0.89

0.83

0.81

0.77

AA488674

Myeloid cell leukemia sequence 1 (BCL2-related)

MCL1

1.58

0.96

X

X

0.84

AA018412

Coiled-coil domain containing 93

CCDC93

1.57

0.92

1.11

1.03

0.85

AA478738

Catenin, beta interacting protein 1

CTNNBIP1

1.55

0.97

0.88

X

1.03

AI652954

Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)

TGM1

1.54

0.67

0.86

1.05

0.56

N59721

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

SERPINE2

1.54

0.69

0.88

X

0.93

AA001432

Laminin, alpha 3

LAMA3

1.53

1.23

0.86

0.94

1.21

AA706099

NEDD4 binding protein 1

N4BP1

1.52

1.08

1.01

1.19

0.98

N33214

Matrix metallopeptidase 14 (membrane-inserted)

MMP14

1.52

0.84

0.79

1.26

0.91

B. Genes up-regulated by infection with RSV

AA406373

Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

TAP2

1.46

2.28

1.10

1.18

1.27

AA620877

Protein tyrosine phosphatase, receptor type, M

PTPRM

X

2.11

1.10

1.18

1.27

R07870

Baculoviral IAP repeat-containing 3; inhibitor of apoptosis protein

-

3.09

2.09

1.20

1.79

1.60

AA701353

Hypothetical protein LOC92270

LOC92270

0.79

2.07

0.90

1.34

2.45

AA001983

Hypothetical LOC92482

LOC92482

0.83

1.74

1.08

NA

X

AI014782

Trinucleotide repeat containing 6B

TNRC6B

1.22

1.99

1.08

0.86

1.88

H80712

Caspase 10, apoptosis-related cysteine peptidase

CASP10

X

1.73

0.79

X

1.84

H23077

Rho family GTPase 1

RND1

X

1.71

X

NA

1.75

AA903644

Protocadherin beta 19 pseudogene

PCDHB19P

0.84

1.65

X

X

1.67

AI085559

Arylacetamide deacetylase-like 1

AADACL1

1.80

1.64

NA

1.69

1.79

H01197

Pleckstrin homology domain containing, family F (with FYVE domain) member 2

PLEKHF2

0.96

1.63

0.87

0.87

1.35

R36431

Fibronectin type III domain containing 3A

FNDC3A

1.37

1.62

0.92

1.03

1.41

AA047413

Zinc finger protein 23 (KOX 16)

ZNF23

NA

1.60

1.18

X

1.20

AA903552

Lysozyme-like 1, lysozyme-like 2

LYZL1, LYZL2

X

1.58

NA

NA

1.79

AA485438

Ring finger protein 187

RNF187

0.84

1.58

1.02

0.86

1.18

R92801

CD47 molecule

CD47

1.68

1.57

1.01

1.16

1.64

AI168153

Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8

PLEKHA8

X

1.57

X

X

1.41

AA878257

Colony stimulating factor 1

CSF1

X

1.57

NA

NA

1.13

AA418724

Zinc finger CCCH-type, antiviral 1

ZC3HAV1

2.82

1.53

1.31

1.77

1.49

AI004484

Zinc finger protein 318

ZNF318

X

1.52

1.29

NA

1.62

C. Genes up-regulated by infection with TIGR4

T65736

Selenium-binding protein

SELENBP1

3.98

0.65

1.35

1.12

NA

AI093729

ADAM metallopeptidase with thrombospondin type 1 motif, 2

ADAMTS2

3.87

1.61

1.59

0.59

NA

AA443000

Granulocyte colony stimulating factor receptor

CSF3R

2.75

1.43

0.89

1.10

0.93

AA460304

Human ribosomal DNA complete repeating unit

CRISPLD2

2.58

NA

1.27

NA

0.75

AI003033

Neural cell adhesion molecule 2

NCAM2

2.56

1.50

1.43

1.36

0.97

AA904923

HNF1 homeobox B

HNF1B

2.34

0.65

1.40

NA

1.30

AA521362

CR2/CD21/c3d/Epstein-Barr virus receptor complement component receptor 2

CR2

2.33

NA

1.15

NA

0.99

T98262

General transcription factor IIIC, polypeptide 3

GTF3C3

2.33

0.96

1.50

NA

0.72

AA904604

RIKEN

LOC143678

2.21

1.11

0.80

1.46

0.95

AI188215

Neuregulin 1

NRG1

2.21

NA

0.91

NA

0.80

W60968

Myelin protein zero-like protein2; Epithelial V-like antigen 1 precursor

MPZL2

2.19

NA

2.47

NA

0.36

R88767

Protocadherin 10; protocadherin 20 precursor

PCDH20

2.13

0.72

1.34

NA

0.81

R01281

Src kinase-associated phosphoprotein1; SKAP55 protein

SKAP55

1.94

NA

1.22

NA

1.17

AA150694

LY6/PLAUR domain containing 6

LYPD6

1.85

NA

1.26

NA

1.08

AA707615

Chromosome 9 open reading frame 116

C9orf116

1.83

0.73

1.05

NA

0.87

H57180

Phospholipase C-like phospholipase C, gamma 2 (phosphatidylinositol-specific)

PLCG2

1.82

NA

1.23

NA

1.09

AA883775

Metallaproteinase-disintegrin

ADAM30

1.80

0.32

1.19

NA

2.26

AI361560

Homeo box C9

HOXC9

1.76

0.59

0.91

0.89

0.93

AI380234

C1qr(p) complement component C1q receptor

CD93

1.76

0.55

NA

0.56

NA

R86733

Zinc finger protein

ZNF397

1.74

NA

1.59

NA

1.10

R08109

Alu subfamily J sequence contamination warning entry

ZNF398

1.70

1.02

0.96

0.81

1.05

AA176413

F-box protein Fbx20

FBX20

1.70

0.36

1.08

NA

1.09

H90292

Procollagen type V alpha 2

SERPINA1

1.70

1.77

0.94

1.47

0.76

AA680249

Bactericidal/permeability-increasing protein

BPI

1.69

1.20

2.06

1.24

NA

R43755

Intraflagellar transport protein 57 homolog

ESRRBL1

1.68

1.35

1.28

0.97

1.05

AA620742

Xenotropic and polytropic retrovirus receptor

XPR1

1.67

1.37

0.87

0.82

1.00

AA137073

Integrin, beta-like 1 (with EGF-like repeat domains)

ITGBL1

1.66

0.81

1.03

0.74

0.99

T70368

Integrin, beta 5

ITGB5

1.66

1.03

1.09

1.64

1.01

R76099

Toll-like receptor 3

TLR3

1.62

0.58

0.83

NA

0.85

H52352

Complement factor properdin

CFP

1.62

NA

1.54

NA

0.54

R98903

Scavenger receptor class B, member 1

SCARB1

1.59

NA

1.01

NA

0.73

AA150507

Interleukin 1, beta

IL1B

1.59

1.99

1.81

1.17

0.56

T98612

Alpha-1 type III collagen

COL3A1

1.57

1.74

0.83

NA

1.06

T52330

Interleukin 6 receptor

IL6R

1.57

1.36

1.06

1.07

1.17

AA010600

Nuclear RNA export factor 3

NXF3

1.56

1.58

1.23

0.99

1.00

AA176249

Transforming growth factor, beta 2

TGFB2

1.56

0.64

0.87

NA

1.18

R10099

Stabilin-2

STAB2

1.56

0.98

1.10

1.18

1.21

N32241

Zinc finger protein 160

ZNF160

1.55

NA

1.10

NA

1.06

W94121

Tumor necrosis factor receptor superfamily, member 19

TNFRSF19

1.55

1.17

1.06

0.53

0.92

H93115

Ras association (ralgds/AF-6) and pleckstrin homology domains 1

RAPH1

1.54

1.56

0.72

0.80

NA

AA455067

Non-Ab component of amyloid peptide precursor

SNCA

1.54

NA

1.14

NA

0.93

R68721

Apo-2 ligand, TNF-related apoptosis inducing ligand TRAIL

TNFSF10

1.54

NA

0.83

NA

1.24

AA456622

Wiskott-Aldrich syndrome protein interacting protein

WIPF1

1.54

NA

1.16

NA

1.00

H74265

Protein tyrosine phosphatase, receptor type, C

PTPRC

1.53

NA

1.15

NA

1.20

T68892

Secreted apoptosis related protein 2

SFRP1

1.52

NA

0.95

1.17

1.16

AA780815

Alpha-2 type VIII collagen

COL8A2

1.50

0.98

1.14

1.43

0.83

  1. Genes listed are up-regulated by infection with HPIV3 (A), RSV (B), and/or TIGR4 (C).
  2. X indicates genes that did not meet the criteria established for microarray analysis (see Methods); NA indicates data points that had no single value.
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