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Table 1 Differential expression of cell adhesion molecules

From: Transcriptional adaptation of pneumococci and human pharyngeal cells in the presence of a virus infection

A. Genes up-regulated by infection with HPIV3
    Fold change
GB# Gene name Gene symbol HPIV3-infected/mock-infected RSV-infected/mock-infected TIGR4-infected/mock-infected HPIV3-TIGR4-infected/mock-infected RSV-TIGR4-infected/mock-infected
AA406020 ISG15 ubiquitin-like modifier ISG15 23.80 1.10 1.05 24.76 1.15
AA456886 Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 MX1 23.68 1.11 1.04 16.12 1.12
AA286908 Myxovirus (influenza virus) resistance 2 MX2 13.84 1.06 1.05 12.35 1.04
T95113 Radical S-adenosyl methionine domain containing 2 RSAD2 11.72 0.90 1.11 4.49 1.39
AA126958 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 DDX58 11.55 1.16 0.88 9.94 0.96
AA419251 Interferon induced transmembrane protein 1 (9-27) IFITM1 7.32 0.96 0.99 5.88 0.76
AA421603 SAM domain and HD domain 1 SAMHD1 5.67 0.96 0.89 4.80 0.86
AI245550 Phospholipid scramblase 1 PLSCR1 5.00 0.91 0.95 3.36 1.11
AA995904 TCF3 (E2A) fusion partner TFPT 4.05 1.35 1.05 4.12 0.91
AA827287 Interferon-induced protein 35 IFI35 3.85 1.10 0.95 3.40 1.00
H54629 Tumor necrosis factor (ligand) superfamily, member 10 TNFSF10 3.64 NA 1.18 4.32 NA
AA862371 Interferon induced transmembrane protein 2 (1-8D) IFITM2 3.37 0.85 0.92 2.18 0.93
AA877255 Interferon regulatory factor 7 IRF7 3.25 X 1.06 2.13 0.71
R07870 Baculoviral IAP repeat-containing 3; inhibitor of apoptosis protein - 3.09 2.09 1.20 1.79 1.60
AI038270 Eukaryotic translation initiation factor 2-alpha kinase 2 EIF2AK2 2.91 1.11 0.99 1.56 1.04
AA479795 Interferon stimulated exonuclease gene 20kda ISG20 2.91 NA 1.10 2.29 NA
N67034 Interferon-induced protein 44-like IFI44L 2.87 1.01 1.05 2.90 0.94
AA418724 Zinc finger CCCH-type, antiviral 1 ZC3HAV1 2.82 1.53 1.31 1.77 1.49
N75384 Peroxisome proliferator-activated receptor gamma, coactivator 1 beta PPARGC1B 2.45 0.78 0.94 NA 0.58
W37864 Phosphatase and tensin homolog PTEN 2.43 0.90 0.93 1.05 0.78
H17861 Ring finger protein 213 RNF213 2.26 1.05 1.03 1.14 1.02
AA983252 Signal transducer and activator of transcription 2, 113kda STAT2 2.23 X 1.12 1.53 NA
R70479 Tumor necrosis factor, alpha-induced protein 3 TNFAIP3 2.17 0.75 1.03 NA 0.73
AA128561 Collagen, type XVII, alpha 1 COL17A1 1.95 1.11 1.99 1.16 1.15
AI016022 NLR family, CARD domain containing 5 NLRC5 1.93 X X X 0.94
N70463 B-cell translocation gene 1, anti-proliferative BTG1 1.90 1.43 1.13 NA 1.39
H61758 ELK4, ETS-domain protein (SRF accessory protein 1) ELK4 1.86 0.80 0.87 NA 1.03
R33456 Desmoplakin DSP 1.82 1.03 0.88 1.18 0.86
AI085559 Arylacetamide deacetylase-like 1 AADACL1 1.80 1.64 X 1.69 1.79
AA609992 Dehydrogenase/reductase (SDR family) member 9 DHRS9 1.78 1.45 0.95 1.09 1.50
AA136060 Polycomb group ring finger 5 PCGF5 1.74 0.99 0.96 1.21 0.82
AI364513 Scavenger receptor class B, member 2 SCARB2 1.72 1.06 NA NA 0.97
AA491191 Interferon, gamma-inducible protein 16 IFI16 1.72 1.38 0.94 0.97 1.99
AA451844 Microtubule associated monoxygenase, calponin and LIM domain containing 2 MICAL2 1.70 0.91 0.91 X 0.79
R92801 CD47 molecule CD47 1.68 1.57 1.01 1.16 1.64
R93911 Glycogen synthase kinase 3 beta GSK3B 1.68 1.29 NA NA 1.32
AA776304 Pleckstrin 2 PLEK2 1.67 0.97 NA 1.81 1.08
AA490894 Endoplasmic reticulum aminopeptidase 1 ERAP1 1.67 1.19 0.87 X 1.25
AA777854 Ring finger protein 12 RNF12 1.67 0.85 0.99 NA 0.92
AA040699 ELK3, ETS-domain protein (SRF accessory protein 2) ELK3 1.65 0.99 0.91 X 0.86
H95362 Claudin 1 CLDN1 1.64 0.83 NA 1.26 1.20
AA411757 Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) CEACAM1 1.63 X NA 1.41 0.51
AA284668 Plasminogen activator, urokinase PLAU 1.63 1.15 1.27 X 1.25
AA135422 CCR4-NOT transcription complex, subunit 1 CNOT1 1.63 0.99 0.89 1.04 1.05
AI049712 Epidermal growth factor receptor EGFR 1.62 1.00 0.91 1.13 0.96
N70848 Ring finger protein 141 RNF141 1.58 1.11 0.94 1.08 0.90
AA005112 LIM domain 7 LMO7 1.58 0.89 0.83 0.81 0.77
AA488674 Myeloid cell leukemia sequence 1 (BCL2-related) MCL1 1.58 0.96 X X 0.84
AA018412 Coiled-coil domain containing 93 CCDC93 1.57 0.92 1.11 1.03 0.85
AA478738 Catenin, beta interacting protein 1 CTNNBIP1 1.55 0.97 0.88 X 1.03
AI652954 Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) TGM1 1.54 0.67 0.86 1.05 0.56
N59721 Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 SERPINE2 1.54 0.69 0.88 X 0.93
AA001432 Laminin, alpha 3 LAMA3 1.53 1.23 0.86 0.94 1.21
AA706099 NEDD4 binding protein 1 N4BP1 1.52 1.08 1.01 1.19 0.98
N33214 Matrix metallopeptidase 14 (membrane-inserted) MMP14 1.52 0.84 0.79 1.26 0.91
B. Genes up-regulated by infection with RSV
AA406373 Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) TAP2 1.46 2.28 1.10 1.18 1.27
AA620877 Protein tyrosine phosphatase, receptor type, M PTPRM X 2.11 1.10 1.18 1.27
R07870 Baculoviral IAP repeat-containing 3; inhibitor of apoptosis protein - 3.09 2.09 1.20 1.79 1.60
AA701353 Hypothetical protein LOC92270 LOC92270 0.79 2.07 0.90 1.34 2.45
AA001983 Hypothetical LOC92482 LOC92482 0.83 1.74 1.08 NA X
AI014782 Trinucleotide repeat containing 6B TNRC6B 1.22 1.99 1.08 0.86 1.88
H80712 Caspase 10, apoptosis-related cysteine peptidase CASP10 X 1.73 0.79 X 1.84
H23077 Rho family GTPase 1 RND1 X 1.71 X NA 1.75
AA903644 Protocadherin beta 19 pseudogene PCDHB19P 0.84 1.65 X X 1.67
AI085559 Arylacetamide deacetylase-like 1 AADACL1 1.80 1.64 NA 1.69 1.79
H01197 Pleckstrin homology domain containing, family F (with FYVE domain) member 2 PLEKHF2 0.96 1.63 0.87 0.87 1.35
R36431 Fibronectin type III domain containing 3A FNDC3A 1.37 1.62 0.92 1.03 1.41
AA047413 Zinc finger protein 23 (KOX 16) ZNF23 NA 1.60 1.18 X 1.20
AA903552 Lysozyme-like 1, lysozyme-like 2 LYZL1, LYZL2 X 1.58 NA NA 1.79
AA485438 Ring finger protein 187 RNF187 0.84 1.58 1.02 0.86 1.18
R92801 CD47 molecule CD47 1.68 1.57 1.01 1.16 1.64
AI168153 Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 PLEKHA8 X 1.57 X X 1.41
AA878257 Colony stimulating factor 1 CSF1 X 1.57 NA NA 1.13
AA418724 Zinc finger CCCH-type, antiviral 1 ZC3HAV1 2.82 1.53 1.31 1.77 1.49
AI004484 Zinc finger protein 318 ZNF318 X 1.52 1.29 NA 1.62
C. Genes up-regulated by infection with TIGR4
T65736 Selenium-binding protein SELENBP1 3.98 0.65 1.35 1.12 NA
AI093729 ADAM metallopeptidase with thrombospondin type 1 motif, 2 ADAMTS2 3.87 1.61 1.59 0.59 NA
AA443000 Granulocyte colony stimulating factor receptor CSF3R 2.75 1.43 0.89 1.10 0.93
AA460304 Human ribosomal DNA complete repeating unit CRISPLD2 2.58 NA 1.27 NA 0.75
AI003033 Neural cell adhesion molecule 2 NCAM2 2.56 1.50 1.43 1.36 0.97
AA904923 HNF1 homeobox B HNF1B 2.34 0.65 1.40 NA 1.30
AA521362 CR2/CD21/c3d/Epstein-Barr virus receptor complement component receptor 2 CR2 2.33 NA 1.15 NA 0.99
T98262 General transcription factor IIIC, polypeptide 3 GTF3C3 2.33 0.96 1.50 NA 0.72
AA904604 RIKEN LOC143678 2.21 1.11 0.80 1.46 0.95
AI188215 Neuregulin 1 NRG1 2.21 NA 0.91 NA 0.80
W60968 Myelin protein zero-like protein2; Epithelial V-like antigen 1 precursor MPZL2 2.19 NA 2.47 NA 0.36
R88767 Protocadherin 10; protocadherin 20 precursor PCDH20 2.13 0.72 1.34 NA 0.81
R01281 Src kinase-associated phosphoprotein1; SKAP55 protein SKAP55 1.94 NA 1.22 NA 1.17
AA150694 LY6/PLAUR domain containing 6 LYPD6 1.85 NA 1.26 NA 1.08
AA707615 Chromosome 9 open reading frame 116 C9orf116 1.83 0.73 1.05 NA 0.87
H57180 Phospholipase C-like phospholipase C, gamma 2 (phosphatidylinositol-specific) PLCG2 1.82 NA 1.23 NA 1.09
AA883775 Metallaproteinase-disintegrin ADAM30 1.80 0.32 1.19 NA 2.26
AI361560 Homeo box C9 HOXC9 1.76 0.59 0.91 0.89 0.93
AI380234 C1qr(p) complement component C1q receptor CD93 1.76 0.55 NA 0.56 NA
R86733 Zinc finger protein ZNF397 1.74 NA 1.59 NA 1.10
R08109 Alu subfamily J sequence contamination warning entry ZNF398 1.70 1.02 0.96 0.81 1.05
AA176413 F-box protein Fbx20 FBX20 1.70 0.36 1.08 NA 1.09
H90292 Procollagen type V alpha 2 SERPINA1 1.70 1.77 0.94 1.47 0.76
AA680249 Bactericidal/permeability-increasing protein BPI 1.69 1.20 2.06 1.24 NA
R43755 Intraflagellar transport protein 57 homolog ESRRBL1 1.68 1.35 1.28 0.97 1.05
AA620742 Xenotropic and polytropic retrovirus receptor XPR1 1.67 1.37 0.87 0.82 1.00
AA137073 Integrin, beta-like 1 (with EGF-like repeat domains) ITGBL1 1.66 0.81 1.03 0.74 0.99
T70368 Integrin, beta 5 ITGB5 1.66 1.03 1.09 1.64 1.01
R76099 Toll-like receptor 3 TLR3 1.62 0.58 0.83 NA 0.85
H52352 Complement factor properdin CFP 1.62 NA 1.54 NA 0.54
R98903 Scavenger receptor class B, member 1 SCARB1 1.59 NA 1.01 NA 0.73
AA150507 Interleukin 1, beta IL1B 1.59 1.99 1.81 1.17 0.56
T98612 Alpha-1 type III collagen COL3A1 1.57 1.74 0.83 NA 1.06
T52330 Interleukin 6 receptor IL6R 1.57 1.36 1.06 1.07 1.17
AA010600 Nuclear RNA export factor 3 NXF3 1.56 1.58 1.23 0.99 1.00
AA176249 Transforming growth factor, beta 2 TGFB2 1.56 0.64 0.87 NA 1.18
R10099 Stabilin-2 STAB2 1.56 0.98 1.10 1.18 1.21
N32241 Zinc finger protein 160 ZNF160 1.55 NA 1.10 NA 1.06
W94121 Tumor necrosis factor receptor superfamily, member 19 TNFRSF19 1.55 1.17 1.06 0.53 0.92
H93115 Ras association (ralgds/AF-6) and pleckstrin homology domains 1 RAPH1 1.54 1.56 0.72 0.80 NA
AA455067 Non-Ab component of amyloid peptide precursor SNCA 1.54 NA 1.14 NA 0.93
R68721 Apo-2 ligand, TNF-related apoptosis inducing ligand TRAIL TNFSF10 1.54 NA 0.83 NA 1.24
AA456622 Wiskott-Aldrich syndrome protein interacting protein WIPF1 1.54 NA 1.16 NA 1.00
H74265 Protein tyrosine phosphatase, receptor type, C PTPRC 1.53 NA 1.15 NA 1.20
T68892 Secreted apoptosis related protein 2 SFRP1 1.52 NA 0.95 1.17 1.16
AA780815 Alpha-2 type VIII collagen COL8A2 1.50 0.98 1.14 1.43 0.83
  1. Genes listed are up-regulated by infection with HPIV3 (A), RSV (B), and/or TIGR4 (C).
  2. X indicates genes that did not meet the criteria established for microarray analysis (see Methods); NA indicates data points that had no single value.