Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes

Vigone, Giulia; Merico, Valeria; Prigione, Alessandro; Mulas, Francesca; Sacchi, Lucia; Gabetta, Matteo; Bellazzi, Riccardo; Redi, Carlo Alberto; Mazzini, Giuliano; Adjaye, James; Garagna, Silvia; Zuccotti, Maurizio

doi:10.1186/1471-2164-14-380

Table 1 List of 247 differentially expressed genes within each of the 11 main biological processes

From: Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes

Gene symbol	Biological process	Number of genes
Agrp, Ahrr, Arhgap15, Bcar3, Cabp4, Ccbp2, Cenpj, Clec4a3, Cx3cr1, Dclk2, Dnaja1, Edg2, Emr1, Enpp2, F10, Ffar3, Fgf15, Fgf5, Freq, Gabrb2, Gem, Gnat3, Gpr182, Gpr85, Grb7, Htr4, Ifnz, Irs1, Kremen2, Lag3, Ms4a10, Npffr2, Olfr104, Olfr1040, Olfr1105, Olfr1208, Olfr1219, Olfr1347, Olfr1383, Olfr1424, Olfr244, Olfr323, Olfr725, Olfr915, Omp, Oscar, Pdyn, Plcg2, Ppp1r1a, Ppp1r1b, Pth2, Ptpn6, Rab9b, Rassf9, Rgma, Rgs6, Rgs9, Rgs9bp, Rin1, Rl1, Rsu1, Sag, Shc4, Tmod2, Trem1, Treml2, Trpc5, Trpm3, V1rh5, Vmn2r42, Zap70, Zcrhav1	Signal transduction	72
Batf2, Chd1l, Cux2, Dhfr, Dis3, Ell3, Fhit, *Giyd2,* Gtf2h5, Gtf3c6, Hmbox1, *Hspa1a,* Il33, Kif18a, Larp6, Mef2b, Nono, Orc4l, P42pop, Rbm35a, Sp5, Tasp1, Tuba4a, Utp15, Zfp1, Zfp526, Zfp786, Zscan2	Nucleic acid metabolism	28
493444A2Rik, Agbl1, Alg11, B3gnt8, Cct6b, Cpeb2, Ctrl, Dnajc4, Dph5, EG623661, Eif3h, Eif4e, Fbxo44, Hipk4, Klhl13, Mrpl15, Mrpl39, Otub2, Rpl22l1, Senp6, Sh3d19, St3gal1, St8sia4, Tor2a, Usp45, Wnk2	Protein metabolism	26
Aif1, Alox12, Bik, Bnipl, C5ar1, Cacybp, Casp1, Casp4, Dapk2, Grid2, Isg20l1, *Lgmn,* Moap1, Nuak2, Pdcl3, Srgn, Tnfrsf4, Tnfsf13b, Tns4, Tpt1, Ube2z, Ywhae	Cell death	22
A930038C07Rik, Azgp1, Cdh1, Cdh11, Cdh13, Cdh3, Cldn3, Cml4, Col12a1, Col3a1, Ctnna3, Lypd3, Magi3, Mia1, Myh8, Pcdhb20, Pcdhb4, Serpini1, Spon2, Tecta, Utrn, Zan	Cell adhesion	22
*Amh, Cited2,* Dazl, Fgf17, Fkbp6, Ggnbp1, Ghrh, Gnrhr, Has2, Hsf2, Mtl5, Pgr, Plau, Sox8, Spag6, Tcp11, Theg, Vmo1	Reproduction	17
AI428936, Abca5, Dixdc1, Dlk2, *Erdr1,* Fig4, Gdf10, Irf8, Lhx3, Lrg1, Neu2, Nkx2-3, Plk4, Rpgr, *Vim*	Cell differentiation	15
Abcc2, Atp5e, Cox7b, Fxyd1, Gjb1, Hvcn1, Kcns1, Kctd7, Ranbp2, Slc25a13, Slc29a4, Slc39a1, Timm22	Transmembrane transport	13
Actl6b, Amn, Bin3, Cdx1, Cftr, Des, Ebf1, Eln, Fnbp1, Hydin, Myl6b, Prr15	Development	12
Alox5ap, Cpt1c, Cyp4f14, Elovl2, Fabp5, Idi1, Ihpk3, Ndufab1, Pigw, Pnliprp2, Ptgds	Lipid metabolism	11
Cdkn2a, Gbx2, Gm606, Il13, Pttg1, Tnfrsf9, Txnrd1, Wfdc1	Cell cycle	8

Regular font, down-regulated genes; bold font, up-regulated genes.

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