Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis

Rajasekaran, Subbiah; Reddy, Narsa M; Zhang, Wei; Reddy, Sekhar P

doi:10.1186/1471-2164-14-381

Table 2 Differentially expressed genes induced by bleomycin in lung tissues of Fra-1 ^+/+ and Fra-1 ^∆/∆ mice

From: Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis

Affymetrix ID	Symbol	Gene title	KOT vs. WTT (fold change)
Cytokine, chemokines, and their receptors
10531415	Cxcl10	C-X-C motif chemokine 10	2.54
10379535	Ccl8	Chemokine (C-C motif) ligand 8	2.27
10520452	Il6	Interleukin 6	2.23
10469278	Il2ra	Interleukin-2 receptor alpha chain	2.15
10487588	Il1a	Interleukin-1 alpha	1.87
10430344	Il2rb	Interleukin 2 receptor, beta chain	1.69
10523128	Ppbp	Chemokine (C-X-C motif) ligand 7	–2.17
10345752	Il1r2	Interleukin 1 receptor, type II	−2.27
Inflammation
10531126	Igj	Immunoglobulin joining chain	17.25
10496555	Gbp1	Guanylate binding protein 1	7.88
10403069	Igh-6	Immunoglobulin heavy constant mu	7.43
10545569	Reg3g	Regenerating islet-derived 3 gamma	4.61
10502801	H28	Histocompatibility 28	3.3
10364542	CFD	Complement factor D	3.09
10563602	Saa4	Serum amyloid A 4	2.81
10576757	Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	2.41
10466172	Ms4a1	Membrane-spanning 4-domains, subfamily A, member 1	2.39
10562169	Hamp	Hepcidin antimicrobial peptide	2.38
10551025	Cd79a	CD79A antigen	2.11
10531987	Gbp4	Guanylate binding protein 4	2.11
10437224	Mx2	Myxovirus (influenza virus) resistance 2	2.1
10441233	Mx1	Interferon-induced GTP-binding protein Mx1	1.96
10500677	CD2	CD2 antigen	1.85
10450675	H2-T24	Histocompatibility 2, T region locus 24	1.81
10451287	Isg15	ISG15 ubiquitin-like modifier	1.81
10531994	Mpa2l	Guanylate binding protein 6	1.79
10398121	Bdkrb1	Bradykinin receptor, beta 1	1.76
10399710	Rsad2	Radical S-adenosyl methionine domain containing 2	1.75
10435982	Btla	B and T lymphocyte associated	1.74
10468898	Lax1	Lymphocyte transmembrane adaptor 1	1.71
10547894	CD4	CD4 antigen	1.7
10444821	H2-Q8	Histocompatibility 2, Q region locus 8	1.69
10444236	H2-DMb2	Histocompatibility 2, class II, locus Mb2	1.67
10372652	Lyz1	Lysozyme 1	1.66
10574098	Nlrc5	NOD-like receptor C5	1.66
10601385	Tlr13	Toll-like receptor 13	−1.66
10560242	C5ar1	Complement component 5a receptor 1	−1.72
10541614	Clec4d	C-type lectin domain family 4, member d	−1.78
10347335	Slc11a1	Solute carrier family 11, member 1	−1.85
10416837	Irg1	Immunoresponsive gene 1	−2.08
10493831	S100a8	S100 calcium binding protein A8	−2.63
10349648	Ctse	Cathepsin E	−2.77
Cell adhesion molecule
10433172	Glycam1	Glycosylation dependent cell adhesion molecule 1	1.98
10500677	CD2	CD2 antigen	1.85
10450675	H2-T24	Histocompatibility 2, T region locus 24	1.81
10547894	CD4	CD4 antigen	1.7
10444821	H2-Q8	Histocompatibility 2, Q region locus 8	1.69
10444236	H2-DMb2	Histocompatibility 2, class II, locus Mb2	1.67
10562720	Siglece	Sialic acid binding Ig-like lectin E	−1.78
10557862	Itgam	Integrin alpha M	−2.04
Transcription
10404389	Irf4	Interferon regulatory factor 4 (TF)	2.06
10585276	Pou2af1	POU class 2 associating factor 1	2.09
10562812	Spib	Spi-B transcription factor (Spi-1/PU.1 related) (TF)	1.83
10360406	Ifi205	interferon activated gene 205	1.65
10390691	Nr1d1	Nuclear receptor subfamily 1, group D, member 1 (TF)	1.7
10460585	Fosl1	Fos-like antigen 1	−1.85

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