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Table 4 Validation of uniquely expressed genes induced by bleomycin in lung tissues from both Fra-1 +/+ and Fra-1 ∆/∆ mice

From: Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis

Affymetrix ID Symbol Gene title Micro array qRT-PCR
    WTT vs. WTC KOT vs. KOC WTT vs. WTC KOT vs. KOC
    Fold change Fold change Fold change Fold change
10540085 Fbln2 Fibulin 2 2.28 ND 2.35 ± 0.27* ND
10531737 Hpse Heparanase ND 1.98 ND 1.57 ± 0.10*
10587266 Gclc Glutamate-cysteine ligase, catalytic subunit ND 1.70 ND 1.58 ± 0.27*
10509030 Runx3 Run related transcription factor 3 ND 2.02 ND 1.30 ± 0.14*
10359697 Xcl1 Chemokine (C motif) ligand 1 ND 2.15 ND 2.57 ± 0.48*
10531420 Cxcl11 Chemokine (C-X-C motif) ligand 11 ND 2.53 ND 4.72 ± 2.33*
10590242 Ccr8 Chemokine (C-C motif) receptor 8 ND 2.13 ND 1.58 ± 0.00NS
10574213 Ccl22 Macrophage-derived chemokine ND 2.42 ND 1.73 ± 0.54NS
10576973 Col4a1 Collagen, type IV, alpha 1 1.96 ND 1.83 ± 1.08NS ND
10416230 Tnfrsf10b Tumor necrosis factor receptor superfamily, member 10b 2.03 ND 2.30 ± 1.09NS ND
10357261 Marco Macrophage receptor with collagenous structure ND 2.03 3.08 ± 0.11* 2.23 ± 0.21*
10433776 Snai2 Snail homolog 2 (Drosophila) ND -1.92 -2.23* -3.50 ± 1.95*
  1. Data are presented as mean ± SD (n=3-4). *P<0.05, PBS vs bleomycin of same genotype. NS means non significant. Result did not agree with microarray result.