Figure 2

Genome wide linkage analyses in BXD RI strains. The QTL scan was performed for all traits, but we illustrate only the trait with the most significant LRS scores for each set of traits that were mapped to the same QTL interval. a. QTL scan for total fat content in adipose tissue (GeneNetwork Record ID 15084). A significant QTL was mapped on Chr 12. This QTL region had also effects on the contents of saturated and unsaturated fat, acyl chain length, collagen content and integrity, and the ratio of lipid to protein. b. QTL scan for the ratio of lipid to protein in the liver (GeneNetwork Record ID 15094). A significant QTL was mapped on Chr 17. This QTL region was overlapping with the contents of total and saturated fat and acyl chain length. The numbers on the top of figures represent chromosomes. The y-axis and the bold blue function provide the LRS (LRS=4.6 x LOD) values. The two horizontal dashed lines indicate the genome-wide significant (upper line) and suggestive thresholds (lower line) at p<0.05 and p<0.63, respectively. The thin red and green lines indicate the average additive effects of D2 (green) and B6 (red) alleles at particular markers. c. The heat map shows QTL regions for different traits obtained by ATR-FTIR spectroscopy. Overlapping QTL regions were detected on chromosomes 12 and 17 in epididymal adipose tissue, liver, and muscle. Intense colors show chromosomal regions with high linkage statistics (LRS) and the spectrum encodes the allelic effect. These figures are directly taken from GeneNetwork [62].