Figure 3

Phylogenetic reconstruction of tissues and single cell clones in both mice. (A) Phylogenetic tree of tissues, with mouse 1 in black and mouse 2 in orange, overlaid. Numbers at bifurcations indicate Bayesian posterior probabilities. (B) Phylogenetic tree of single cell clones in mouse 1. Only branch structures with larger than 50% posterior probability are shown. Pairs of single cell clones from the same parental cell are marked with asterisks. (Mouse 2 shown in Additional file 8: Figure S2) (C) Distribution of N-bar symmetry statistic for mouse 1 tissue trees with highest posterior probabilities compared to random trees with the same number of branches, showing a symmetric nature of the actual tissue trees. Examples of symmetric (left, N-bar = 4) and asymmetric trees (right, N-bar = 7.43) are shown. (Equivalent distribution for the I _c symmetry statistic are shown in Additional file 8: Figure S3).