Figure 6

Model defining STAT-mediated common and cell-type specific gene regulation. STATs regulate gene sets upon binding to cognate GAS sites located in STAT-controlled CRMs (SCCs). A) Common Global STAT targets. 116 common STAT controlled CRMs (CSCCs) have been identified. These CSCCs bind any STAT member in every cell type tested. B) STAT controlled cell-specific CRMs. STAT binding coincides with cell-specific transcription factor binding as exemplified for liver and adipocytes. STAT5 binding in liver tissue and adipocytes coincides with genes that are also recognized by HNF4A and CEBPB, respectively.